Dysfunction of melanocytes in photoleukomelanoderma following photosensitivity caused by hydrochlorothiazide
Dysfunction of melanocytes in photoleukomelanoderma following photosensitivity caused by hydrochlorothiazide
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氢氯噻嗪引起光敏性后的光性白斑黑素细胞功能障碍
DOI：
10.1111/j.1600-0781.2011.00614.x
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Nishigori C
中科院分区：
文献类型：
--
作者：
Masuoka E;Bito T;Shimizu H;Nishigori C
我们报告了一名68岁的日本男性，他在氢氯噻嗪引起的长期光敏性后患上了光性白斑黑斑病。在停用有效药物并局部应用他克莫司水合物和皮质类固醇后，患者显示从白黑皮肤病中完全恢复。组织学和免疫组织化学检查显示，尽管存在黑素细胞，但色素减退区域中没有黑素阳性细胞。这些结果和临床过程表明，白斑黑变病是假定的暂时性功能障碍的黑素细胞。我们还对既往关于药物诱导的光性白斑黑斑病的病例报告进行了审查。
We report a 68‐year‐old Japanese man who developed photoleukomelanoderma following prolonged photosensitivity caused by hydrochlorothiazide. He showed complete recovery from the leukomelanoderma with the discontinuation of the responsive drug and with topical application of tacrolimus hydrate and corticosteroid. Histological and immunohistochemical examination revealed that there were no melanin‐positive cells in the hypopigmented area, despite the presence of melanocytes. These results and the clinical course indicate that leukomelanoderma is postulated temporary dysfunction of melanocytes. We also conducted a review of previous case reports regarding drug‐induced photoleukomelanoderma.