Resistance, resistance, go away: persistence of nevirapine-resistant HIV mutations in HIV-infected infants.
Resistance, resistance, go away: persistence of nevirapine-resistant HIV mutations in HIV-infected infants.
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耐药性、耐药性、消失：艾滋病毒感染婴儿中奈韦拉平耐药性艾滋病毒突变的持续存在。
DOI：
10.1097/qad.0b013e3283463d44
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Paintsil,Elijah
中科院分区：
文献类型：
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作者：
Paintsil,Elijah
在本期杂志中，Fogel et al. [1]报告称，在马拉维的婴儿暴露后预防（PEPI）试验中，暴露于艾滋病毒的婴儿接受了为期14周的奈韦拉平（NVP）或NVP+齐多夫定（NVP+ ZDV）扩展方案，108名14周龄的艾滋病毒感染婴儿中有82名（75.9%）检测到NVP耐药。在扩展的仅NVP组中，6个月和12个月时NVP耐药的患病率分别为85.0%和56.3%。对于扩展NVP+ ZDV组，6个月和12个月时NVP耐药的患病率分别为80.8%和76.9%。首先，作者对我们理解围产期抗逆转录病毒药物预防后耐药性演变的贡献值得赞扬。正如这篇评论的标题所暗示的，下面的讨论是基于一首流行的童谣中的隐喻-"雨，雨，走开，改天再来.“。据说“雨，雨，走开”歌词的起源可以追溯到女王伊丽莎白一世（1533-1603; http：//www.yahoo.com）统治时期。押韵org.uk）。在她统治期间，伟大的西班牙阿尔马达试图入侵英格兰。他们被英国人击败，不仅是因为英国小型船只的快速行动，而且是因为不利的暴风雨天气。人们不得不肯定幼儿园学生唱这首童谣时的感染力和天真，更不用说最佳战略赢得战斗的教训了。
In this issue of the journal, Fogel et al.[1] report that in the Post-Exposure Prophylaxis of Infants (PEPI) Trial in Malawi, HIV-exposed infants were given an extended regimen of either nevirapine (NVP) or NVP with zidovudine (NVP+ ZDV) for 14 weeks, NVP resistance was detected in 82 (75.9%) of 108 HIV-infected infants at 14 weeks of age. In the extended NVP only arm, the prevalence of NVP resistance at 6 and 12 months was 85.0 and 56.3%, respectively. With the extended NVP+ ZDV arm, the prevalence of NVP resistance at 6 and 12 months was 80.8 and 76.9%, respectively. First, the authors are to be commended for their contribution to our understanding of the evolution of resistance after perinatal antiretroviral chemoprophylaxis.As the title of this commentary implies, the following discussion is based on metaphors drawn from a popular nursery rhyme–‘rain, rain, go away, come again another day...’. The origin of the lyrics to ‘rain, rain, go away’is said to date back to the reign of Queen Elizabeth I (1533–1603; http://www. rhymes. org. uk). During her reign, the great Spanish Armada attempted to invade England. They were defeated by the English not only because of the swift action of the smaller English ships but also by the unfavorable stormy weather. One cannot help but affirm the infectious vigor and naiveté with which nursery pupils chant this rhyme, not to mention the lesson that best strategies win battles.