Sarcopenia, sarcopenic obesity, and functional impairments in older adults: National Health and Nutrition Examination Surveys 1999-2004.
Sarcopenia, sarcopenic obesity, and functional impairments in older adults: National Health and Nutrition Examination Surveys 1999-2004.
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DOI：
10.1016/j.nutres.2015.09.003
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发表时间：
2015-12
期刊：
影响因子：
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通讯作者：
Bartels SJ
中科院分区：
文献类型：
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作者：
Batsis JA;Mackenzie TA;Lopez-Jimenez F;Bartels SJ
美国国立卫生研究院基金会（FNIH）肌肉减少症项目验证了非典型瘦体重（ALM）的临界点，以识别功能障碍的个体。我们假设根据不同的FNIH标准，肌肉减少症和肌肉减少性肥胖症的患病率相似，随年龄增加，并与损伤限制的风险相关。我们从1999-2004年国家健康和营养检查调查中确定了4，984名≥60岁的受试者。肌肉减少症使用以下定义：ALM（男性<19.75kg;女性<15.02kg），和针对体重指数（BMI）调整的ALM（男性<0.789;女性<0.512）。肌肉萎缩性肥胖定义为符合肌肉减少症和肥胖标准的受试者（男性≥25%;女性≥35%）。根据性别、年龄类别（60-69岁、70-79岁、> 80岁）和种族评估肌肉减少症和肌肉减少性肥胖症的患病率。我们评估了身体限制、基本和工具性日常生活活动（ADL）和肌肉减少症状态之间的关系。男性平均年龄为70.5岁，女性为71.6岁。一半（50.8%，n= 2，531）为女性，男女的平均BMI均为28 kg/m2。男性的ALM高于女性（24.1 vs. 16.3; p<0.001），但脂肪量较低（30.9 vs. 42.0;p<0.001）。在男性中，使用ALM和ALM/BMI标准的肌肉减少症患病率分别为16.0%和27.8%。在女性中，使用ALM和ALM/BMI标准的患病率分别为40.5%和19.3%。在男性和女性中，使用ALM和ALM/BMI定义，肌肉减少分别与1.10 [0.86，1.41]和0.93 [0.74，1.16]以及1.46 [1.10，1.94]和2.13 [1.41，3.20]的身体限制风险相关。肌肉减少症和肌肉减少性肥胖症的患病率差异很大，需要一个统一的定义来识别和表征这些高危人群。
The Foundation for the NIH (FNIH) Sarcopenia Project validated cutpoints for appendicular lean mass (ALM) to identify individuals with functional impairment. We hypothesized the prevalence of sarcopenia and sarcopenic obesity would be similar based on the different FNIH criteria, increase with age, and be associated with risk of impairment limitations. We identified 4,984 subjects ≥60 years from the National Health and Nutrition Examination Surveys 1999–2004. Sarcopenia was defined using: ALM (males<19.75kg; females<15.02kg), and ALM adjusted for body mass index (BMI) (males<0.789; females<0.512). Sarcopenic obesity is defined as subjects fulfilling criteria for sarcopenia and obesity by body fat (men≥25%; females≥35%). Prevalence rates of both sarcopenia and sarcopenic obesity were evaluated with respect to sex, age category (60–69, 70–79, >80years) and race. We assessed the association of physical limitations, basic and instrumental activities of daily living (ADL) and sarcopenia status. The mean age was 70.5 years in males and 71.6 years in females. Half (50.8%, n=2,531) were female, and mean BMI was 28kg/m2 in both sexes. ALM was higher in males than in females (24.1 vs. 16.3; p<0.001) but fat mass was lower (30.9 vs. 42.0;p<0.001). In males, sarcopenia prevalence was 16.0% and 27.8% using the ALM and ALM/BMI criteria. In females, prevalence was 40.5% and 19.3% using the ALM and ALM/BMI criteria. Sarcopenia was associated with a 1.10 [0.86,1.41] and 0.93 [0.74,1.16], and 1.46 [1.10,1.94] and 2.13 [1.41,3.20], risk of physical limitations using the ALM and ALM/BMI definitions in males and females, respectively. Prevalence of sarcopenia and sarcopenic obesity vary greatly, and a uniform definition is needed to identify and characterize these high risk populations.