Single droplets to particles - size, shape, shell thickness and porosity analyses using X-ray computed tomography
Single droplets to particles - size, shape, shell thickness and porosity analyses using X-ray computed tomography
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DOI：
10.1016/j.ces.2021.116879
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发表时间：
2021-06
影响因子：
4.7
通讯作者：
H. Abdullahi;Petros Neoptolemou;C. Burcham;T. Vetter
中科院分区：
文献类型：
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作者：
H. Abdullahi;Petros Neoptolemou;C. Burcham;T. Vetter
通过声悬浮研究了结晶和表皮形成物质的单液滴的干燥动力学，以提供模拟喷雾干燥操作的良好控制的环境。通过干燥含有不同比例的D-甘露醇和聚乙烯吡咯烷酮（PVP）的水溶液液滴制造的颗粒进行了分析，使用一系列的技术，以阐明其形态和微观结构。所制造的颗粒的尺寸、孔隙率和表面粗糙度随着D-甘露醇在水中的浓度而增加，而球形度降低，这是独特形态的结果。发现颗粒壳厚度的变化是最小的。考虑不同比例的PVP导致了各种迷人的结构，与纯D-甘露醇制造的那些形成对比。进一步考虑了温度的影响，结果与实验室和中试规模的喷雾干燥器的结果相匹配。固体形式的分析进一步证明了制备D-甘露醇的不同多晶型形式的机会。
The drying kinetics of single droplets of crystallizing and skin-forming species were investigated via acoustic levitation to provide a well-controlled environment mimicking spray drying operations. Particles manufactured by drying aqueous solution droplets containing varying ratios of D-mannitol and polyvinylpyrrolidone (PVP) were analysed using a range of techniques to elucidate their morphology and microstructure. Size, porosity and surface roughness of the manufactured particles increased with D-mannitol concentration in water, while the sphericity decreased, a consequence of the unique morphologies. The change in particle shell thickness was found to be minimal. Considering varying proportions of PVP led to a variety of fascinating structures, contrasting to those manufactured from pure D-mannitol. Temperature effects were further considered, and the results were matched by that from a lab and pilot scale spray dryer. Analysis of the solid form further demonstrates the opportunity to prepare different polymorphic forms of D-mannitol.