Synthesis of sequential polydepsipeptides utilizing a new approach for the synthesis of depsipeptides
Synthesis of sequential polydepsipeptides utilizing a new approach for the synthesis of depsipeptides
复制标题
利用缩酚肽合成新方法合成连续聚缩酚肽
作者：
R. Katakai;K. Kobayashi;Keiichi Yamada;H. Oku;N. Emori
采用缩酚肽活性酯法合成了连续聚缩酚肽，采用了一种从羟基酸直接合成 N 保护的缩酚肽游离酸的新方法。该方法通过游离羟基酸与Boc-氨基酸N-羟基琥珀酰亚胺酯在4-二甲基氨基吡啶催化下反应合成Boc-二缩酚肽，并通过与Boc-氨基酸N-羟基琥珀酰亚胺酯在乙腈-四氢呋喃有机溶剂体系中反应来延长游离缩酚肽的链。 Boc-缩酚肽游离酸被活化为其 N-羟基琥珀酰亚胺酯，在去除 Boc 保护基团后聚合。 © 2004 Wiley periodicals, Inc. 生物聚合物，2004
Sequential polydepsipeptides were synthesized by the depsipeptide active ester method using a new approach for the direct synthesis of N‐protected depsipeptide free acids from hydroxy acids. The method uses synthesis of Boc‐didepsipeptides by reaction of free hydroxy acids with Boc‐amino acid N‐hydroxysuccinimide esters catalyzed by 4‐dimethylaminopyridine and chain elongation of the free depsipeptides by the reaction with Boc‐amino acid N‐hydroxysuccinimide esters in an organic solvent system of acetonitrile‐tetrahydrofuran. The Boc‐depsipeptide free acids were activated as their N‐hydroxysuccinimide esters, which were polymerized after removal of the Boc‐protecting group. © 2004 Wiley Periodicals, Inc. Biopolymers, 2004