Phosphoinositide lipids in primary cilia biology.
Phosphoinositide lipids in primary cilia biology.
复制标题
初级纤毛生物学中的磷脂酰肌醇脂类。
DOI：
10.1042/bcj20200277
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发表时间：
2020-09-30
期刊：
影响因子：
--
通讯作者：
Vanhaesebroeck B
中科院分区：
文献类型：
--
作者：
Conduit SE;Vanhaesebroeck B
初级纤毛是从大多数细胞类型的表面突出的孤立的信号细胞器。虽然纤毛膜与质膜是连续的，但它表现出独特的磷脂成分，这是正常纤毛形成和功能所必需的特征。最近的研究表明，不同的磷脂酰肌醇脂质种类定位于特定的纤毛亚结构域，并已开始建立一个'磷脂酰肌醇地图'的纤毛。磷脂酰肌醇的丰度和定位受到最近在纤毛中发现的脂质激酶和脂质磷酸酶的相反作用的严格调节。纤毛相关的磷酸肌醇调节酶的遗传缺陷导致人类和实验小鼠和斑马鱼模型中纤毛病表型的破坏性后果突出了磷酸肌醇在纤毛生物学中的关键作用。在这里，我们提供了一个一般性的介绍，初级纤毛和作用磷酸肌醇发挥纤毛生物学。除了增加我们对基础纤毛生物学的理解外，这个快速扩展的领域可能会为治疗由磷酸肌醇代谢失调引起的纤毛病综合征提供新的方法。
Primary cilia are solitary signalling organelles projecting from the surface of most cell types. Although the ciliary membrane is continuous with the plasma membrane it exhibits a unique phospholipid composition, a feature essential for normal cilia formation and function. Recent studies have illustrated that distinct phosphoinositide lipid species localise to specific cilia subdomains, and have begun to build a ‘phosphoinositide map’ of the cilium. The abundance and localisation of phosphoinositides are tightly regulated by the opposing actions of lipid kinases and lipid phosphatases that have also been recently discovered at cilia. The critical role of phosphoinositides in cilia biology is highlighted by the devastating consequences of genetic defects in cilia-associated phosphoinositide regulatory enzymes leading to ciliopathy phenotypes in humans and experimental mouse and zebrafish models. Here we provide a general introduction to primary cilia and the roles phosphoinositides play in cilia biology. In addition to increasing our understanding of fundamental cilia biology, this rapidly expanding field may inform novel approaches to treat ciliopathy syndromes caused by deregulated phosphoinositide metabolism.
DOI：
10.1016/j.bbrc.2011.06.168
发表时间：
2011-07-29
影响因子：
3.1
作者：
Xia, Yang;Irvine, Robin F.;Giudici, Maria-Luisa
通讯作者：
Giudici, Maria-Luisa
影响因子：
3.5
作者：
Giudici, Maria-Luisa;Lee, Koon;Lim, Rongxuan;Irvine, Robin F.
通讯作者：
Irvine, Robin F.