Explicit verbal memory impairments associated with brain functional deficits and morphological alterations in patients with generalized anxiety disorder
Explicit verbal memory impairments associated with brain functional deficits and morphological alterations in patients with generalized anxiety disorder
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DOI：
10.1016/j.jad.2015.07.038
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发表时间：
2015-11-01
影响因子：
6.6
通讯作者：
Jeong, Gwang-Woo
中科院分区：
文献类型：
--
作者：
Moon, Chung-Man;Yang, Jong-Chul;Jeong, Gwang-Woo
背景：广泛性焦虑障碍（GAD）与脑功能和形态学改变有关。本研究探讨了广泛性焦虑症患者的外显文字记忆障碍，包括脑功能缺陷和形态学改变。方法：17例广泛性焦虑症患者和17名年龄、性别和教育水平相匹配的健康对照者在3 T条件下进行了高分辨率TI加权MRI和fMR成像，记录了情绪中性和焦虑诱导词的外显文字记忆任务。在对中性词的反应中，与健康对照组相比，患者的海马（Hip）、中扣带回（MCG）、壳核（Pu）和尾状核头部（HCd）区域的活动显著降低。在对焦虑诱发词的反应中，患者的腹外侧前额叶皮层和中央前回的活动显着增加。但Hip、MCG、Pu和HCd的活性较低。此外，与健康对照组相比，广泛性焦虑症患者的灰质体积显著减少，尤其是在髋关节、中脑、丘脑、小脑和上级颞回区域。局限性：本研究检查了每组的小样本量，并且没有考虑药物对大脑活动和体积变化的影响。本研究为广泛性焦虑症患者在外显言语记忆任务中的脑功能缺陷和形态测量学改变之间的关联提供了证据。这一发现有助于理解外显言语记忆障碍与广泛性焦虑症症状的关系。(C)2015 Elsevier B.V.. All rights reserved.
Background: Generalized anxiety disorder (GAD) is associated with brain function and morphological alterations. This study investigated explicit verbal memory impairment in patients with GAD in terms of brain functional deficits in combination with morphologic changes.Methods: Seventeen patients with GAD and 17 healthy controls matched for age, sex, and education level underwent high-resolution TI-weighted MRI and fMR imaging at 3 T during explicit verbal memory tasks with emotionally neutral and anxiety-inducing words.Results: In response to the neutral words, the patients showed significantly lower activities in the regions of the hippocampus (Hip), middle cingulate gyms (MCG), putamen (Pu) and head of the caudate nucleus (HCd) compared with healthy controls. In response to the anxiety-inducing words, the patients showed significantly higher activities in the ventrolateral prefrontal cortex and precentral gyrus. However, they showed lower activities in the Hip, MCG, Pu and HCd. In addition, patients with GAD showed a significant reduction in gray matter volumes, especially in the regions of the Hip, midbrain, thalamus, insula and superior temporal gyms, compared with healthy controls.Limitations: This study examined a small sample sizes in each of the groups, and there was no consideration of a medication effect on brain activity and volume changes.Conclusions: This study provides evidence for the association between brain functional deficits and morphometric alterations in an explicit verbal memocy task for patients with GAD. This finding is helpful for understanding explicit verbal memory impairment in connection with GAD symptoms. (C) 2015 Elsevier B.V.. All rights reserved.