Regulatory myeloid suppressor cells in health and disease.
Regulatory myeloid suppressor cells in health and disease.
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DOI：
10.1158/0008-5472.can-09-2152
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发表时间：
2009-10-01
期刊：
影响因子：
11.2
通讯作者：
Gabrilovich DI
中科院分区：
文献类型：
--
作者：
Nagaraj S;Collazo M;Corzo CA;Youn JI;Ortiz M;Quiceno D;Gabrilovich DI
近年来的研究已经带来了大量关于免疫抑制性骨髓细胞在癌症和其他疾病中的重要作用的信息。越来越多的证据表明，这些调节细胞的扩增可能代表了对所有形式炎症的共同反应。一些临床试验针对这些细胞，目的是改善癌症的免疫反应。然而，该领域以及术语“调节性髓样细胞”是非常有争议的，许多问题仍然没有解决。2009年3月8日至11日在佛罗里达克利尔沃特举行的国际会议上讨论了这些问题。大约240名研究人员致力于研究骨髓源性抑制细胞（MDSC），调节（抑制）树突状细胞，以及癌症，感染性疾病，败血症，创伤和自身免疫性疾病中的抑制性巨噬细胞。来自不同研究领域的参与者有机会评估有关癌症和其他疾病免疫学背景下免疫抑制性骨髓细胞的扩增，积累，分化，调节和功能的数据。
Research in recent years has brought a wealth of information about the important role of immune suppressive myeloid cells in cancer and other diseases. There is growing evidence suggesting that the expansion of these regulatory cells may represent a common response to all forms of inflammation. Several clinical trials target these cells with the goal of improving the immune response in cancer. However, the field as well as the term ‘‘regulatory myeloid cells’’is highly controversial, and many issues remain unresolved. These issues were discussed at the international meeting in Clearwater, Florida held from March 8 through 11, 2009. Approximately 240 researchers working on myeloidderived suppressor cells (MDSC), regulatory (suppressive) dendritic cells, as well as suppressive macrophages in cancer, infectious diseases, sepsis, trauma, and autoimmune diseases convened. Participants from different fields of research were provided with the opportunity to assess the data about expansion, accumulation, differentiation, regulation, and function of immune suppressive myeloid cells within the context of immunology of cancer and other diseases.