Cortisol Stress Reactivity to the Trier Social Stress Test in Obese Adults
Cortisol Stress Reactivity to the Trier Social Stress Test in Obese Adults
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DOI：
10.1159/000493533
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发表时间：
2018-01-01
期刊：
影响因子：
3.6
通讯作者：
Petrowski, Katja
中科院分区：
文献类型：
--
作者：
Herhaus, Benedict;Petrowski, Katja
目的：全世界约有6亿成年人患有肥胖症。除了个体的饮食行为和缺乏体育活动导致肥胖和超重，心理社会压力以及激素应激反应也必须被认为是重要的影响因素。在当前的研究中，我们比较了肥胖个体和正常体重对照者在心理社会应激诱导（Trier Social stress Test； TSST）中的皮质醇应激反应途径。方法：32例肥胖患者（女性17例，平均年龄33.94岁，SD = 11.31岁）和32例正常体重对照者（女性17例，平均年龄29.09岁，SD = 10.46岁）进行TSST检查。测量唾液皮质醇反应和3份评估问卷（初级评估、二级评估、视觉模拟量表、特里尔慢性应激量表）。结果：应激诱导后，肥胖个体的皮质醇水平与正常体重对照组有显著的主组差异，肥胖个体的基线水平和应激后皮质醇水平较低。肥胖组与正常体重组在应激状态自我评价上无显著差异，但在应激状态认知评价上有显著差异。结论：综上所述，肥胖个体与正常体重对照组在心理社会应激诱导方面存在皮质醇模式差异。此外，目前的数据表明，肥胖导致皮质醇活性降低，这可能表明下丘脑-垂体-肾上腺皮质（HPA）轴的改变。(C) 2018作者：s . Karger GmbH，弗莱堡出版
Objective: Approximately 600 million adults worldwide suffer from obesity. In addition to individual's eating behavior and lack of physical activity in the development of obesity and overweight, psychosocial stress as well as hormonal stress reactivity must also be considered as important contributing factors. In the current study we compared the cortisol stress response pathway in a psychosocial stress induction (Trier Social Stress Test; TSST) with obese individuals and normal-weight controls. Method: 32 obese individuals (17 females; mean age = 33.94 years, SD = 11.31 years) and 32 normal-weight controls (17 females; mean age = 29.09 years, SD = 10.46 years) underwent the TSST. The salivary cortisol responses and three appraisal questionnaires (Primary Appraisal Secondary Appraisal, Visual Analogue Scale, Trier Inventory for Chronic Stress) were measured. Results: After stress induction, there was a significant main group difference between the obese individuals and the normal-weight controls for cortisol, with lower baseline and post-stress cortisol levels in the obese individuals. Nevertheless, the obese individuals as well as the normal-weight controls showed no significant difference in the self-reported assessment of the stress condition but some significant differences in the cognitive appraisal of the TSST. Conclusion: In conclusion, the induction of psychosocial stress showed differences in the cortisol patterns between the obese individuals and the normal-weight controls. Furthermore, the present data suggest that obesity leads to lower cortisol activity, which may indicate alterations in the Hypothalamic-pituitary-adrencortical (HPA) axis. (C) 2018 The Author(s) Published by S. Karger GmbH, Freiburg