Histologic Grade Predicts Recurrence for Marginally Excised Canine Subcutaneous Soft Tissue Sarcomas
Histologic Grade Predicts Recurrence for Marginally Excised Canine Subcutaneous Soft Tissue Sarcomas
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DOI：
10.1354/vp.08-vp-0277-m-fl
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发表时间：
2009-09-01
影响因子：
2.4
通讯作者：
McSporran, K. D.
中科院分区：
文献类型：
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作者：
McSporran, K. D.
边缘切除的皮下软组织肉瘤的局部复发是可变的，难以预测。本研究旨在确定切除活检后局部复发的预测因素。分析了2004年至2007年期间收到的236只肿瘤犬的医疗记录。中型至大型犬，中位年龄10岁，最常见的影响。共有139例肿瘤进行了组织学分级：71例为1级（51%）; 59例为2级（42%）; 9例为3级（7%）。其中，34个肿瘤（25%）被完全切除，104个（75%）被边缘切除。有随访资料的30例完全切除肿瘤均无复发。41例1级肿瘤中有3例（7%），41例2级肿瘤中有14例（34%），4例3级肿瘤中有3例在边缘切除后复发。生成Kaplan-Meier生存曲线以评价生存和无肿瘤间隔。采用对数秩检验和趋势对数秩检验进行比较。患有1级和2级肿瘤的犬与患有1级和3级肿瘤的犬的肿瘤无复发间隔显著不同（分别为P = .0027和.0001），总体上与肿瘤分级呈负相关（P = .0007）。Kaplan-Meier生存曲线，不考虑复发，对于1级、2级或3级肿瘤患者，边缘切除治疗无显著差异，与完全切除治疗患者的生存曲线无差异。总之，组织学分级是边缘切除的皮下软组织肉瘤复发的一个强有力的预测因子。切缘干净预示不会复发。肿瘤复发并没有显著减少生存时间。
Local recurrence of marginally excised subcutaneous Soft tissue sarcomas is variable and difficult to predict. This Study aimed to identify predictors of local recurrence after excisional biopsy. Medical records of 236 dogs from which tumors had been received between 2004 and 2007 were analyzed. Medium- to large-breed dogs, median age 10 years, were most commonly affected. A total of 139 tumors were graded histologically: 71 were grade 1 (51%); 59, grade 2 (42%); and 9, grade 3 (7%). Of these, 34 tumors (25%) were completely excised, and 104 (75%) were marginally excised. None of 30 completely excised tumors with follow-up information recurred. Three of 41 grade 1 tumors (7%), 14 of 41 grade 2 tumors (34%), and 3 Out of 4 grade 3 tumors recurred after marginal excision. Kaplan-Meier Survival curves were generated to evaluate survival and the tumor-free interval. The log-rank test and log-rank test for trend were used for comparisons. Tumor recurrence-free intervals for dogs with grade 1 and 2 tumors and for those with grade 1 and 3 tumors differed significantly (P = .0027 and .0001, respectively) and overall were inversely related to tumor grade (P = .0007). Kaplan-Meier survival curves, regardless of recurrence, for patients with grade 1, 2, or 3 tumors treated by marginal excision did not differ significantly, and none differed from the Survival curves of patients treated by complete excision. In conclusion, histologic grade is a strong predictor for recurrence of marginally excised subcutaneous Soft tissue sarcomas. Clean margins predict nonrecurrence. Tumor recurrence did not significantly reduce survival time.