Editorial: Low renin "essential'' hypertension; a variant of classic primary aldosteronism?
Editorial: Low renin "essential'' hypertension; a variant of classic primary aldosteronism?
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社论：低肾素“原发性”高血压；经典原发性醛固酮增多症的一种变体？
DOI：
10.1001/archinte.1975.00330020151022
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发表时间：
1975
影响因子：
--
通讯作者：
C. Grim
中科院分区：
文献类型：
--
作者：
C. Grim
自从杰罗姆W.医学博士康恩提出，在美国有300万例未确诊的原发性醛固酮增多症，这让高血压研究人员感到震惊。[1]与Rovner和Cohen博士一起，确定了原发性醛固酮增多症的新诊断标准，从那时起，低钾血症、醛固酮生成升高、血浆肾素活性抑制和糖皮质激素生成正常的组合成为经典原发性醛固酮增多症的标志。2这种典型的综合征通常与大的（直径大于1.5 cm）肾上腺腺瘤有关，但也可能与双侧肾上腺增生有关。切除这种异常的肾上腺组织通常可以治愈高血压和醛固酮增多症的相关表现。在1965年和1966年，Conn等3，4报道了与较小的肾上腺肿瘤（直径5 mm）相关的第一例血钾正常的原发性醛固酮增多症，并认为这代表了早期阶段
It has been ten years since Jerome W. Conn, MD, astounded hypertension researchers by suggesting that there were 3,000,000 cases of undiagnosed primary aldosteronism in the United States. 1 In conjunction with Drs. Rovner and Cohen, new criteria for the diagnosis of primary aldosteronism were defined and since that time the combination of hypokalemia, elevated aldosterone production, suppressed plasma renin activity, and normal glucocorticoid production has been the hallmark of classic primary aldosteronism. 2 This classic syndrome is generally associated with a large (greater than 1.5 cm in diameter) adrenal adenoma but may also be associated with bilateral adrenal hyperplasia. The removal of this abnormal adrenal tissue usually cures the hypertension and the associated manifestations of hyperaldosteronism. In 1965 and 1966, Conn et al 3,4 reported the first cases of normokalemic primary aldosteronism associated with smaller adrenal tumors (5 mm in diameter) and suggested that this represented an earlier phase