The EVcouplings Python framework for coevolutionary sequence analysis.
The EVcouplings Python framework for coevolutionary sequence analysis.
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用于协同进化序列分析的Evcouplings Python框架。
DOI:
10.1093/bioinformatics/bty862
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发表时间:
2019-05-01
期刊:
影响因子:
--
通讯作者:
Marks DS
中科院分区:
文献类型:
--
作者:
Hopf TA;Green AG;Schubert B;Mersmann S;Schärfe CPI;Ingraham JB;Toth-Petroczy A;Brock K;Riesselman AJ;Palmedo P;Kang C;Sheridan R;Draizen EJ;Dallago C;Sander C;Marks DS
Coevolutionary sequence analysis has become a commonly used technique for de novo prediction of the structure and function of proteins, RNA, and protein complexes. We present the EVcouplings framework, a fully integrated open-source application and Python package for coevolutionary analysis. The framework enables generation of sequence alignments, calculation and evaluation of evolutionary couplings (ECs), and de novo prediction of structure and mutation effects. The combination of an easy to use, flexible command line interface and an underlying modular Python package makes the full power of coevolutionary analyses available to entry-level and advanced users. https://github.com/debbiemarkslab/evcouplings
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