Progesterone receptor participates in the stimulatory effect of LHRH, prostaglandin E2, and cyclic AMP on lordosis and proceptive behaviours in rats
Progesterone receptor participates in the stimulatory effect of LHRH, prostaglandin E2, and cyclic AMP on lordosis and proceptive behaviours in rats
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DOI：
10.1046/j.1365-2826.1997.00617.x
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发表时间：
1997-08-01
影响因子：
3.2
通讯作者：
GonzalezMariscal, G
中科院分区：
文献类型：
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作者：
Beyer, C;GonzalezFlores, O;GonzalezMariscal, G
采用黄体生成素释放激素(LHRH)5 mU、前列腺素E_2(PGE_2)100 mU、环磷酸二丁酯(db-cAMP)2 mg，观察了抗孕激素RU486对去卵巢大鼠动情行为(前凸、前倾)的影响。注射上述药物前60min预先给予5 mg RU-486(但不与载体一起注射)，可显著降低由这些药物引起的正常的前凸和操练行为。结果提示，LHRH、PGE2和db cAMP的动情作用是通过激活孕酮受体实现的。
We explored the effect of the antiprogestin RU486 on the estrous behaviour (lordosis and proceptivity) induced in sexually experienced ovariectomized oestrogen primed rats by: 5 mu g luteinizing hormone-releasing hormone (LHRH), 100 mu g prostaglandin E2 (PGE2), or 2 mg dibutyryl cyclic AMP (db cAMP). Pretreatment with 5 mg RU 486 (but not with vehicle) 60 min before the injection of the above-mentioned agents significantly decreased both lordosis and preceptive behaviours normally induced by such agents. Results suggest that the estrus-inducing action of LHRH, PGE2 and db cAMP occurs through the activation of the progesterone receptor.