IMMUNOHISTOCHEMICAL CHARACTERISTICS OF ADENOSQUAMOUS CARCINOMA OF THE PANCREAS
IMMUNOHISTOCHEMICAL CHARACTERISTICS OF ADENOSQUAMOUS CARCINOMA OF THE PANCREAS
复制标题
DOI：
10.1002/jso.2930490114
复制
发表时间：
1992-01-01
影响因子：
2.5
通讯作者：
KANEMATSU, T
中科院分区：
文献类型：
--
作者：
MOTOJIMA, K;TOMIOKA, T;KANEMATSU, T
本文对6例胰腺腺鳞癌进行了临床病理和免疫组织化学研究。在6例ASqC肿瘤中，5例恶性鳞状细胞和腺体成分均与CA19-9、ST439和角蛋白抗体呈阳性反应。另1例ASqC的腺体成分与CA19-9和ST439抗体呈阳性反应，而鳞状细胞癌(SqCC)的腺体成分无反应。然而，该肿瘤的SqCC与角蛋白抗体呈强烈反应。这些免疫组织化学结果表明，1例ASqC肿瘤的组织发生与其他5例ASqC不同，该肿瘤可能是碰撞瘤，而不是从腺癌向SqCC转化，这是ASqC中非常罕见的组织发生模式。胰腺ASQC患者术后生存期较短，因为有全身转移，包括肝脏转移。
Six patients with adenosquamous carcinoma (ASqC) of the pancreas were studied clinicopathologically and immunohistochemically. In five of six ASqC tumors, both malignant squamous and glandular elements were reactive with CA 19-9, ST 439, and keratin antibodies. In contrast, a portion of the glandular element in the remaining one ASqC was reactive with CA 19-9 and ST 439 antibodies, but that of the squamous cell carcinoma (SqCC) was not reactive. However, SqCC of this tumor was intensely reactive with keratin antibody. These immunohistochemical results suggest that the histogenesis in one ASqC tumor was different from that of the other 5 ASqCs, and that this tumor may be a collision tumor rather than transformation to SqCC from adenocarcinoma, which is a very rare pattern of histogenesis in ASqC. The patients with ASqC of the pancreas showed shorter survivals following operations because of systemic metastasis including liver metastasis.