Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB
Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB
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DOI：
10.1074/jbc.274.19.12955
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发表时间：
1999-05-07
影响因子：
4.8
通讯作者：
DiStefano, PS
中科院分区：
文献类型：
--
作者：
Bertin, J;Nir, WJ;DiStefano, PS
线虫CED-4蛋白及其人类同源物Apaf-1通过作为死亡诱导半胱天冬酶的直接激活剂在细胞凋亡中发挥核心作用。一种新的人类CED-4/Apaf-1家族成员CARD 4被鉴定出具有与介导植物抗病性的细胞质受体样蛋白惊人相似的结构域结构。CARD 4与丝氨酸-苏氨酸激酶RICK相互作用，并通过TRAF-6和NIK信号分子有效诱导NF-κ B活性。此外，CARD 4的共表达增强了caspase-9诱导的细胞凋亡。因此，CARD 4协调下游NF-κ B和凋亡信号传导途径，并且可能是宿主先天免疫应答的组分。
The nematode CED-4 protein and its human homolog Apaf-1 play a central role in apoptosis by functioning as direct activators of death-inducing caspases. A novel human CED-4/Apaf-1 family member called CARD4 was identified that has a domain structure strikingly similar to the cytoplasmic, receptor-like proteins that mediate disease resistance in plants. CARD4 interacted with the serine-threonine kinase RICK and potently induced NF-kappa B activity through TRAF-6 and NIK signaling molecules. In addition, coexpression of CARD4 augmented caspase-9-induced apoptosis. Thus, CARD4 coordinates downstream NF-kappa B and apoptotic signaling pathways and may be a component of the host innate immune response.