Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives
Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives
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首发精神分裂症患者及其一级亲属的神经认知缺陷
DOI：
10.1002/ajmg.b.30330
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发表时间：
2007-06-05
影响因子：
2.8
通讯作者：
Li, Tao
中科院分区：
文献类型：
--
作者：
Ma, Xiaohong;Wang, Qiang;Li, Tao
一些神经心理能力，特别是那些影响记忆、注意力和执行功能的能力，在精神分裂症患者和他们未受影响的亲属中都受到损害，这意味着这些缺陷至少部分源于遗传。然而，神经心理表现可以通过药物改变，很少在初发、药物幼稚的患者中进行检查。这项研究的目的是确定与对照组相比，首发精神分裂症患者及其亲属的选定神经认知能力是否受损。对207例首发精神分裂症患者(其中163例为药物未知者)、322名一级亲属和133名无血缘关系的正常对照进行了注意力和信息加工速度、记忆与学习、言语功能、视觉建构能力和执行功能的检测。这些数据经过多水平建模，以比较精神分裂症先证者、亲属和对照组之间的神经认知表现，同时考虑到同一家庭成员之间的潜在相关性；年龄、性别和教育年限作为协变量包括在内。在这三组患者中，精神分裂症患者在所有神经心理测试中表现最差，这表明存在广泛的神经认知缺陷。他们的一级亲属在数字符号、数字跨度、连线、语言流畅性测试、河内塔和WCST-M测试中表现出较差的模式。我们的发现表明，在精神分裂症患者的家庭中，特定的神经认知缺陷，特别是注意力和执行功能受损。这些神经认知缺陷的模式可能代表了表示精神分裂症不同程度易感性的“内表型”，可能在未来的分子遗传学研究中有价值。(C)2007年Wiley-Liss，Inc.
Some neuropsychological abilities, particularly those affecting memory, attention and executive function, are impaired amongst both schizophrenic patients and their unaffected relatives, implying that these deficits are at least partly genetic in origin. However neuropsychological performance can be altered by medication, and has rarely been examined in first onset, drug naive patients. The objective of this study was to determine whether selected neurocognitive abilities are impaired in first-onset schizophrenic patients and their relatives compared to controls. We examined attention and speed of information processing, memory and learning, verbal function, visuoconstructive abilities and executive function in 207 first-episode schizophrenic patients (163 of whom were drug naive), 322 of their first-degree relatives and 133 unrelated normal controls. The data were subjected to multilevel modeling to compare neurocognitive performance between schizophrenic probands, relatives and controls while taking into account potential correlations among members of the same family; age, gender, and years of education were included as covariates. Of the three groups, schizophrenic patients performed poorest at all neuropsychological tests, suggestive of abroad range of neurocognitive deficits. Their first-degree relatives showed a narrower pattern of poor performance at Digit Symbol, Digit Span, Trail Making, Verbal Fluency test, Tower of Hanoi, and WCST-M tests. Our findings show that selected neurocognitive deficits especially attention and executive function are impaired in the families of schizophrenic patients. These patterns of neurocognitive deficits may represent "endophenotypes" denoting varying degrees of vulnerability to schizophrenia and may be of value in future molecular genetic studies. (c) 2007 Wiley-Liss, Inc.