Methylation status of RASSF1A in patients with chronic myeloid leukemia
Methylation status of RASSF1A in patients with chronic myeloid leukemia
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DOI：
10.1016/j.leukres.2009.01.003
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发表时间：
2009-08-01
影响因子：
2.7
通讯作者：
Speletas, Matthaios
中科院分区：
文献类型：
--
作者：
Avramouli, Antigoni;Tsochas, Stefanos;Speletas, Matthaios
RASSF1A是一种关键的细胞周期相关基因，在所有的造血细胞中都有表达，它参与了ras信号转导通路，其启动子高甲基化在多种实体瘤中均可观察到。到目前为止，慢性粒细胞白血病(CML)患者的RASSF1A甲基化状态尚未得到研究。在这项研究中，我们分析了41名携带BCR-ABL重排的患者，这些患者处于疾病的不同阶段。尽管携带bcr-abl重排的K562红白血病细胞系被发现甲基化，但没有患者出现RASSF1A启动子甲基化。因此，我们的发现表明，RASSF1A甲基化似乎并不代表CML的发病和/或进展中的关键步骤。(C)2009爱思唯尔有限公司。保留所有权利。
RASSF1A, a key cell cycle related gene, is expressed in all hematopoietic cells, it is implicated in ras signaling pathway and its promoter hypermethylation is observed in a wide variety of solid tumors. Till now, RASSF1A methylation status has not been investigated in patients with chronic myeloid leukemia (CML). In this study, we analyzed 41 patients carrying the BCR-ABL rearrangement, in different stages of the disease. No patient displayed RASSF1A promoter methylation, although the K562 erythroleukemia cell line, bearing the BCR-ABL rearrangement, was found methylated. Thus, our findings indicate that RASSF1A methylation does not appear to represent a critical step in the pathogenesis and/or the progression of CML. (C) 2009 Elsevier Ltd. All rights reserved.