Peritumoral FOXP3+ regulatory T cell is sensitive to chemotherapy while intratumoral FOXP3+ regulatory T cell is prognostic predictor of breast cancer patients
Peritumoral FOXP3+ regulatory T cell is sensitive to chemotherapy while intratumoral FOXP3+ regulatory T cell is prognostic predictor of breast cancer patients
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DOI：
10.1007/s10549-012-2132-3
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发表时间：
2012-09-01
影响因子：
3.8
通讯作者：
Fu, Li
中科院分区：
文献类型：
--
作者：
Liu, Fangfang;Li, Yaqing;Fu, Li
据报道，乳腺癌中肿瘤浸润性 FOXP3(+) 调节性 T 细胞 (Treg) 的预后意义取决于其相对密度和组织位置。我们在这里评估了新辅助化疗（NC）前后Tregs的变化及其与肿瘤反应和患者生存的关系。采用免疫组织化学方法评估 132 例浸润性乳腺癌切除术前后 FOXP3(+) Tregs 的瘤内和瘤周浸润情况。 NC后，肿瘤床内浸润的Treg细胞密度保持稳定，而肿瘤周围组织中的浸润Treg细胞密度显着下降（P = 0.015）。这些变化在那些通常对 NC 有反应的肿瘤中显着，包括 HER2 富集和基底样亚型（P = 0.035；P = 0.004）。单变量和多变量分析表明，瘤周Treg细胞减少是病理完全缓解（pCR）的独立预测因子，而化疗后瘤内Treg细胞被证明与患者的总生存期和无进展生存期相关。研究结果表明，瘤周Treg对化疗敏感并与pCR相关，而瘤内Treg是乳腺癌患者的独立预后预测因子。
It has been reported that the prognostic significances of tumor-infiltrating FOXP3(+) regulatory T cells (Tregs) in breast carcinoma depend on their relative density and tissue locations. We here assessed the changes of Tregs before and after neoadjuvant chemotherapy (NC) and their relationships with tumor response and patient survival. Intratumoral and peritumoral infiltration of FOXP3(+) Tregs were evaluated by immunohistochemistry in 132 cases of invasive breast carcinomas before and after NC. After NC, the density of infiltrated Tregs within tumor bed remained stable, whereas it decreased significantly (P = 0.015) in the tissue surrounding tumor. The changes were significant in those tumors that usually response to NC, including the HER2-enriched and basal-like subtypes (P = 0.035; P = 0.004). Univariate and multivariate analyses identified the decreased peritumoral Tregs were an independent predictor for pathologic complete response (pCR), while the intratumoral Tregs after chemotherapy was proved to be associated with overall survival and progression-free survival of the patients. The findings of the study indicated that peritumoral Treg was sensitive to chemotherapy and associated with pCR, while intratumoral Treg was an independent prognostic predictor of breast cancer patients.