UNILATERAL ODOR DEPRIVATION - TIME COURSE OF CHANGES IN LAMINAR VOLUME
UNILATERAL ODOR DEPRIVATION - TIME COURSE OF CHANGES IN LAMINAR VOLUME
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DOI：
10.1016/0361-9230(85)90088-7
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发表时间：
1985-01-01
影响因子：
3.8
通讯作者：
BRUNJES, PC
中科院分区：
文献类型：
--
作者：
BRUNJES, PC
当在幼年期检查动物时，第1天单侧嗅觉剥夺导致嗅球大小大幅减少。测量层流体积变化的发展，以确定何时出现嗅球大小的差异。在第1天对大鼠幼崽进行1个鼻孔的手术闭合，并在第4、8或12天检查椎板尺寸。第12天，剥夺和控制灯泡之间出现可靠的差异。为了确定对感觉输入变化敏感的时间长度，在第10天或第20天剥夺幼仔，并饲养30天。在这两个年龄段降低灯泡的大小，虽然在以后的年龄治疗导致不太严重的变化。
Unilateral olfactory deprivation on Day 1 results in large reductions in olfactory bulb size when animals are examined in the juvenile period. The development of changes in laminar volume was measured to determine when differences in olfactory bulb size emerge. Rat pups underwent surgical closure of 1 naris on Day 1 and laminar sizes were examined on either day 4, 8 or 12. Reliable differences emerged between deprived and control bulbs by Day 12. To determine the length of the period of susceptibility to changes in sensory input, pups were deprived on either Day 10 or 20 and reared for 30 days. Deprivation at both ages reduced bulb size, although treatment at the later age resulted in less severe alterations.