PROGRESSIVE FIBRINOID DEGENERATION OF FIBRILLARY ASTROCYTES ASSOCIATED WITH MENTAL RETARDATION IN A HYDROCEPHALIC INFANT
PROGRESSIVE FIBRINOID DEGENERATION OF FIBRILLARY ASTROCYTES ASSOCIATED WITH MENTAL RETARDATION IN A HYDROCEPHALIC INFANT
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DOI：
10.1093/brain/72.3.373
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发表时间：
1949-01-01
期刊：
影响因子：
14.5
通讯作者：
ALEXANDER, WS
中科院分区：
文献类型：
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作者：
ALEXANDER, WS
我们报告了一名15个月大的患有智力迟钝和脑积水的男性患者的临床病史和尸检结果。用Mallory的磷酸钨酸苏木精染色、Alzheimer的酸紫红浅绿色染色、Van Gieson， Spielmeyer髓鞘染色和Hortega的碳酸银染色对中枢神经系统切片进行组织学检查。作者在脑白质、脑膜和脑膜下发现了大量的嗜紫红色小体，但在皮层中却没有发现。这些体主要是血管周围。证据显示这些小体是纤维性神经胶质细胞纤维和细胞体纤维蛋白变性的结果。
The clinical history and autopsy findings are reported of a 15-month-old male with mental retardation and hydrocephalus. Histologic examinations were made of the central nervous system of sections stained by Mallory''s phosphotungstic acid hematoxylin, Alzheimer''s acid fuchsin light green method, Van Gieson, Spielmeyer myelin sheath stain and by Hortega''s silver carbonate. The author found large numbers of fuchsinophil bodies in the white matter and beneath both the epenclyma and pia, but sparing the cortex. These bodies were predominantly perivascular. Evidence is presented to show these bodies are the result of fibrinoid degeneration in the fibers and cell bodies of the fibrillar neuroglia.