Developmental expression of the four plasma membrane calcium ATPase (Pmca) genes in the mouse.
Developmental expression of the four plasma membrane calcium ATPase (Pmca) genes in the mouse.
复制标题
四种质膜钙 ATP 酶 (Pmca) 基因在小鼠中的发育表达。
DOI：
10.1016/s0304-4165(99)00058-6
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Kappen,C
中科院分区：
文献类型：
--
作者：
Zacharias,DA;Kappen,C
The plasma membrane calcium ATPases are critical components in the regulation of cellular calcium homeostasis and signaling. In mammals, there are 4 Pmca genes, and information on the cellular and tissue distribution of their expression during development will provide insight into the regulation and possible function of each Pmca isoform. Using specific probes and in situ hybridization, we found that the four Pmca genes are expressed in spatially overlapping but distinct patterns in the mouse embryo. The dynamic temporal patterns of expression indicate that the individual isoforms are subject to both positive and negative regulation. The differential and restricted expression of Pmca genes supports the notion that they play unique functional roles in mammalian development.
