Cytokine expression in the endometrium of women with implantation failure and recurrent miscarriage
Cytokine expression in the endometrium of women with implantation failure and recurrent miscarriage
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DOI：
10.1016/s1472-6483(10)62011-1
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发表时间：
2006-07-01
影响因子：
4
通讯作者：
Li, T-C
中科院分区：
文献类型：
--
作者：
Laird, Susan;Tuckerman, E. M.;Li, T-C
生育失败的一个潜在原因，如不孕不育和反复流产，可能是子宫内膜缺陷。在小鼠身上的大量研究表明，各种不同的细胞因子在成功妊娠结局中的重要性。本文就辅助性T细胞因子和IL-1、IL-11、LIF、IL-12和IL-18在不孕症和复发性流产中的作用作一综述，重点介绍子宫内膜细胞因子可能发挥的作用。尽管有许多关于细胞因子在反复流产中的研究，但关于它们在体外受精后失败的不孕症中的作用的报道要少得多。各种不同研究的结果也有相当大的差异，这可能是由于所研究的群体不同，样本收集的时间不同，以及细胞因子是在整个组织中还是在特定的细胞群体中测量的。细胞因子复杂网络的存在及其相互重叠的生物学活性意味着一种细胞因子的改变很可能影响其他细胞因子，这也使得对它们在植入失败中的作用的研究变得非常困难。迫切需要通过精心计划和积极设计的研究来重新审视各种细胞因子在生殖失败中所起的作用，并比较不同类型的生殖失败。
One potential cause of reproductive failure such as infertility and recurrent miscarriage may be an endometrial defect. Numerous studies in mice have suggested the importance of various different cytokines in successful pregnancy outcome. This article reviews the literature available on the role of T helper cytokines and IL-1, IL-11, LIF, IL-12 and IL-18 in infertility and recurrent miscarriage, with particular emphasis on the role that endometrial cytokines may play. Although there are numerous studies on cytokines in recurrent miscarriage, much less has been reported on their role in infertility with or without failure after IVF. There is also considerable variation in the results obtained from various different studies, which may be due to different populations studied, the different timing of the sample collection, and whether the cytokines were measured in whole tissue or a specific cell population. The presence of complicated networks of cytokines and their overlapping biological activities means that alteration of one cytokine is likely to affect others and this also makes the study of their role in implantation failure very difficult. There is an urgent need to re-examine the role played by various cytokines in reproductive failure through carefully planned and vigorously designed studies and to compare the different types of reproductive failure.