Early breakdown of the blood-retinal barrier in diabetes.
Early breakdown of the blood-retinal barrier in diabetes.
复制标题
糖尿病血视网膜屏障的早期破坏。
DOI：
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复制
发表时间：
1975
影响因子：
4.1
通讯作者：
Gabriela M. Figo
中科院分区：
文献类型：
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作者：
J. Cunha;J. R. Faria;DE Abreu;J. Campos;Gabriela M. Figo
血-视网膜屏障在视网膜病理生理过程中起着重要作用。通过玻璃体荧光光度法研究血-视网膜屏障的一种新的临床方法似乎满足必要的要求，因为它是定量的，并且显示出良好的再现性和高灵敏度。应用该方法对一系列眼底明显“正常”的糖尿病患者进行研究，发现在糖尿病视网膜受累的早期阶段，血-视网膜屏障存在显著的破坏。细分的程度可以衡量，以便进行比较和演变评价。玻璃体荧光光度法显示血-视网膜屏障的紊乱出现在荧光素血管造影显示微动脉瘤或毛细血管闭合之前。
The blood-retinal barrier plays an important part in the processes of retinal pathophysiology. A new clinical method for the study of the blood-retinal barrier by vitreous fluorophotometry appears to satisfy the necessary requirements in that it is quantitative and shows good reproducibility and high sensitivity. The application of this method to a series of diabetic patients with apparently "normal" fundi revealed the presence of a significant breakdown of the blood-retinal barrier in the early stages of retinal involvement in diabetes. The extent of the breakdown can be measured allowing for comparative and evolutionary evaluations. The disturbance of the blood-retinal barrier, as evidence by vitreous fluorophotometry, appears before microaneurysms or capillary closure can be demonstrated by fluorescein angiography.