Bio-inspired Underwater Super-Oil-wettability for Controlling Platelet Adhesion.
Bio-inspired Underwater Super-Oil-wettability for Controlling Platelet Adhesion.
复制标题
用于控制血小板粘附的仿生水下超级油润湿性。
DOI：
10.1002/asia.202100143
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
U. Manna
中科院分区：
文献类型：
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作者：
Dibyangana Parbat;Bibhas K. Bhunia;B. Mandal;U. Manna
血小板粘附的控制促进和预防对于各种生物医学应用是重要的。在过去，表面形貌和化学改性通常用于定制血小板粘附的促进和预防。最近，荷叶启发的超疏水性已成为防止血小板粘附的有效途径。然而，这种极端的防水界面无法执行后，长期和连续暴露于水phase. In通信，战略使用的无催化剂的胺和丙烯酸酯之间的1，4-共轭加成反应，使我们能够调查两个不同的水下油润湿性对血小板粘附活性的影响。虽然水下superoleophobicity抑制血小板粘附，粘附血小板的高度聚集的纤维网络观察到水下superoleophilic涂层。此外，这种生物相容性和血液相容性的水下超疏油多层涂层沉积在市售导管上，以检查其防止血小板附着的潜力。
Control promotion and prevention of platelet adhesion are important for various biomedical applications. In the past, surface topography and chemical modifications have been commonly utilized for tailoring the promotion and prevention of platelet adhesion. Recently, lotus-leaf-inspired superhydrophobicity has appeared as an efficient avenue to prevent platelet adhesion. However, such extreme water repellent interfaces fail to perform upon prolonged and continuous exposure to aqueous phase. In this communication, the strategic use of a catalyst-free 1,4-conjugate addition reaction between amine and acrylate allowed us to investigate the impact of two distinct underwater oil-wettability on platelet adhesion activity. While underwater superoleophobicity inhibited platelet-adhesion, a highly aggregated fibrous network of adhered platelets was observed on underwater superoleophilic coating. Further, this biocompatible and haemocompatible underwater superoleophobic multilayer coating was deposited on a commercially available catheter tube to examine its potential towards the prevention of platelet attachment.