Predicting the recurrence of chronic rhinosinusitis with nasal polyps using nasal microbiota
Predicting the recurrence of chronic rhinosinusitis with nasal polyps using nasal microbiota
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DOI：
10.1111/all.15168
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发表时间：
2021-11-14
期刊：
影响因子：
12.4
通讯作者：
Zhang, Luo
中科院分区：
文献类型：
--
作者：
Zhao, Yan;Chen, Junru;Zhang, Luo
背景最近的研究表明，慢性鼻窦炎鼻息肉(CRSwNP)患者的鼻腔微生物区系发生了深刻的变化，并与全身炎症有关。然而，关于微生物区系是否可以用来预测鼻息肉复发，人们知之甚少。本研究旨在确定鼻腔微生物区系改变是否可以作为预测CRSwNP复发的生物标志物。方法采用细菌16S核糖体RNA基因测序方法对鼻腔微生物区系组成进行定量分析。选择的绝对收缩最小的特征和基于选择算子回归的预测因子是鼻部微生物群落组成和CRSwNP患者的临床特征。主要结果是复发，这是在入院后确定的。结果通过区分鼻息肉复发相关的微生物区系，并利用鼻息肉复发和未复发患者鼻部微生物区系的差异，我们建立了鼻息肉复发的预测分类器，准确率为91.4%。结论鼻腔微生物群的关键分类特征可预测CRSwNP患者的复发。鼻部微生物群是CRSwNP临床变异的一个未被充分研究的来源，代表了未来预防和治疗的新的治疗靶点。
Background Recent studies have revealed that the nasal microbiota in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) is profoundly altered and is correlated with systemic inflammation. However, little is known regarding whether the microbiota can be utilized to predict nasal polyp recurrence. This study is aimed to determine whether altered nasal microbiota constituents could be used as biomarkers to predict CRSwNP recurrence. Methods Nasal microbiota constituents were quantified and characterized using bacterial 16S ribosomal RNA gene sequencing. Selected features for least absolute shrinkage and selection operator regression-based predictors were the nasal microbiota community composition and CRSwNP patient clinical characteristics. The primary outcome was recurrence, which was determined post-admission. Results By distinguishing recurrence-associated nasal microbiota taxa and exploiting the distinct nasal microbiota abundance between patients with recurrent and non-recurrent CRSwNP, we developed a predictive classifier for the diagnosis of nasal polyps' recurrence with 91.4% accuracy. Conclusions Key taxonomical features of the nasal microbiome could predict recurrence in CRSwNP patients. The nasal microbiome is an understudied source of clinical variation in CRSwNP and represents a novel therapeutic target for future prevention and treatment.