Neurons that subserve the sensory-discriminative aspects of pain
Neurons that subserve the sensory-discriminative aspects of pain
复制标题
促进疼痛感觉辨别方面的神经元
DOI：
10.1016/0304-3959(77)90063-x
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发表时间：
1977
期刊：
影响因子：
7.4
通讯作者：
R. Dubner
中科院分区：
文献类型：
--
作者：
D. Price;R. Dubner
Some modem theoAs~ combine aspects of both theories and consider their model within the fr=~ nework of pan sensation and its reactions [82, 83]. The rote of affective-motJvational sys~ ms in pain has been stressed by Melzack and Casey [82]. They propose that the reticular core of the b~ stem, the medial thalamus, and parts of the thnbic lobe form p~ of an 1 system responsible for the aversive drive and affcctive~ component of pan. The inference of their concev~ ual model [82] and the conciumon of Casey's more recent work [32] are that these central core structures form pm~ of a distinct motiva~ ional-affective pain system tihat is activated separably and in parallel with sensory~ iscAminative pain sys~*. ms. Our purpose ha this review is not to advocate or criticize any particular theory, or to present yet another one, but rather to formulate several lines of evidence which seem to be impoAant and useful in deciding whether a peripheral or central neuron is within sensor T-discriminative pathways which form part of the neural basis of pain in man and, presumably, m other mammalian species. Similar as well as additional lines of evidence will be needed~ o es~ abhsh the role of neuron populations in other aspects of the total pan experience. We are focusing our a~ ention on neurons involved in sensory, discriminative functions since mo~ of our presen~ knowledge is m~ his area.~ n addition, we in~ end to show that at leas~, some neurons whose activation conveys information related to~ he senso~ w-discrhninative component of pain also access neural systems~ hat produce aversive, arousal~ and motor reactions. The separation of~ he~ o $ al pan experience along~ hese dimensions is critical for further analyses of pain pathways and mechanisms Behavioral responses~ o noxious input are extensive and neurons in many brain areas are activated~ a~.~-~¢~ Hv or~ n parallel as a resu~ of such input.~ t would be inappropriate to consider all neurons~ hat responded~ o noxious stimulation as part of a sensory-discfi~ inative pathway. In~ he firs~ par~ of~ his review, we shah discuss lines of evidence by which various types of neurons can b nociceptive~ nformation in an neurons whose function is to n1 (~ ion in ascending pathways, a subjec~ of previous reviews [78~ 81]. Certain combinations of lines of evidence':,~ re necess~ and sufficienf; to infer arole in pah% discrimination. Each line of evidence lisCed below is no~, by itself, sufficient,, lla~. her, it is important~ o de~ ernaine~ by several means, that the neurons' responses covary wi% h parameters of noxious s~; irnuiation and wi~; h parameters of pain in man or at least with behavior by which pain can be inferred. In~ he second p~:~~; o~~ his review we discuss~ in~; he con~ x~ of these lines of evidence,%, he relshve extent to which various types of peripheral and cen%, ra~~ ervous sy~:~:~ neu~'ons can be implicated in pain discrimination.
