Function of FGF signaling in the developmental process of the median fin fold in zebrafish
Function of FGF signaling in the developmental process of the median fin fold in zebrafish
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DOI：
10.1016/j.ydbio.2006.12.040
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发表时间：
2007-04-01
影响因子：
2.7
通讯作者：
Tamura, Koji
中科院分区：
文献类型：
--
作者：
Abe, Gembu;Ide, Hiroyuki;Tamura, Koji
中鳍是鱼类的不成对附肢，是基本的运动器官，被认为是在脊椎动物的成对侧附肢之前进化的。然而，中鳍发展的早期过程在很大程度上仍然未知。我们研究了中鳍褶皱的早期发育，中鳍的雏形，并在这里报告的过程中，斑马鱼胚胎和FGF信号在这个过程中的功能。利用dlx5a，sp9和fgf24三个基因的表达作为褶皱发育不同阶段的标记，我们的研究结果表明，中鳍褶皱发育的早期过程可以分为两个步骤，中鳍褶皱领域的规范和褶皱结构的构建。功能丧失和功能获得试验均显示FGF信号传导在每个步骤中发挥作用，表明中间附属物和成对侧附属物发育的共同机制。(c)2007年爱思唯尔公司All rights reserved.
Median fins, unpaired appendages in fish, are fundamental locomotory organs that are believed to have evolved before paired lateral appendages in vertebrates. However, the early process of median fin development remains largely unknown. We investigated the early development of the median fin fold, a rudiment of median fins, and report here the process in zebrafish embryos and the function of FGF signaling in the process. Using expressions of three genes, dlx5a, sp9 and fgf24, as markers of different phases of fold development, our findings suggest that the early process of median fin fold development can be divided into two steps, specification of the median fin fold territory and construction of the fold structure. Both loss-of-function and gain-of-function assays revealed that FGF signaling plays roles in each step, suggesting a common mechanism for the development of median appendages and paired lateral appendages. (c) 2007 Elsevier Inc. All rights reserved.