Tumor deposit indicates worse prognosis than metastatic lymph node in gastric cancer: a propensity score matching study
Tumor deposit indicates worse prognosis than metastatic lymph node in gastric cancer: a propensity score matching study
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DOI：
10.21037/atm.2019.10.33
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发表时间：
2019-11-01
影响因子：
--
通讯作者：
Han, Fanghai
中科院分区：
文献类型：
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作者：
Tan, Jianan;Yang, Bin;Han, Fanghai
背景：胃癌存款（TD）的预后价值存在争议。方法：选取2007年10月至2012年10月连续收治的胃癌患者为研究对象，分析TD对胃癌预后的影响。患者按是否患有TD分为两组。经倾向评分匹配（PSM）后，两组基本资料具有可比性，然后对两组进行生存分析[总生存期（OS）和癌症特异性生存期（CSS）]。根据pN分期对所有患者进行分组，并对每个亚组进行生存分析。将所有患者分为TD组、pN1期组、pN2期组、pN3a期组和pN3b期组，比较各组患者的OS和CSS。多变量竞争风险分析测试TD与OS和CSS之间的关联，在PSM之前和之后。PSM后，137例TD患者和274例非TD患者的5年OS和CSS率均显著低于非TD患者（OS：19.7% vs.42.0%，P
Background: The prognostic value of tumor deposit (TD) in gastric cancer is controversial. This study aims to investigate the prognostic value of TD.Methods: The consecutive patients diagnosed with gastric cancer from October 2007 to October 2012 were selected. The patients were divided by whether they suffered TD into two groups. The basic data were comparable between the two groups after propensity score matching (PSM), then survival analysis [overall survival (OS) and cancer-specific survival (CSS)] was applied in two groups. After that, all the patients were divided by pN staging and survival analysis were applied in each subgroup. At last, all patients were divided into TD group, pN1 stage group, pN2 stage group, pN3a, and pN3b stage group, OS and CSS were compared between them. Multivariable competing risk analyses tested association of TD with OS and CSS, before and after PSM.Results: Eight hundred and three patients were concluded. After PSM, 137 patients with TD and 274 patients without TD were selected, the 5-year OS and CSS rates of patients with TD were significantly worse than patients without TD (OS: 19.7% vs. 42.0%, P