A combination of exercise and calorie restriction improves the development of obesity-related type 2 diabetes mellitus in KKAy mice
A combination of exercise and calorie restriction improves the development of obesity-related type 2 diabetes mellitus in KKAy mice
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运动和热量限制相结合可改善 KKAy 小鼠肥胖相关 2 型糖尿病的发展
DOI：
10.1093/bbb/zbac170
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Kamei Yasutomi
中科院分区：
文献类型：
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作者：
Sugimoto Takumi;Uchitomi Ran;Onishi Takumi;Kamei Yasutomi
我们观察到运动和热量限制降低了肥胖/糖尿病模型KKAy小鼠的体重和血糖水平，同时改善了胰岛素抵抗和葡萄糖耐量。骨骼肌中的基因表达分析显示GLUT 4（葡萄糖摄取）、ATGL（脂解酶）和慢收缩肌球蛋白重链的mRNA水平增强，这可能有助于抗肥胖和抗糖尿病作用。
We observed that exercise and calorie restriction reduced the body weight and blood glucose levels, concurrently improving insulin resistance and glucose tolerance in obese/diabetic model KKAy mice. Analysis of gene expression in the skeletal muscle showed enhanced mRNA levels of GLUT4 (glucose uptake), ATGL (lipolytic enzyme), and slow-twitch myosin heavy chain, which may contribute to the antiobesity and antidiabetic effects.