Novel Applications of Radionuclide Imaging in Peripheral Vascular Disease.
Novel Applications of Radionuclide Imaging in Peripheral Vascular Disease.
复制标题
放射性核素成像在周围血管疾病中的新应用。
DOI：
10.1016/j.ccl.2015.06.005
复制
发表时间：
2016
影响因子：
2.4
通讯作者：
Sinusas,AlbertJ
中科院分区：
文献类型：
--
作者：
Stacy,MitchelR;Sinusas,AlbertJ
外周血管疾病（PVD）是一种进行性动脉粥样硬化疾病，可导致下肢供血血管狭窄或闭塞。目前的诊断成像技术通常侧重于评价大血管水平的解剖结构或血流，而不允许评估与疾病进展或治疗反应相关的潜在病理生理学。基于放射性核素的分子成像方法，如PET和SPECT，可以通过提供对血管生成和动脉粥样硬化等生物过程的非侵入性评估，为PVD提供新的见解。这篇综述讨论了新兴的放射性核素为基础的成像方法，有潜在的临床应用在评估PVD的进展和治疗。
Peripheral vascular disease (PVD) is a progressive atherosclerotic disease that leads to stenosis or occlusion of blood vessels supplying the lower extremities. Current diagnostic imaging techniques commonly focus on evaluation of anatomy or blood flow at the macrovascular level and do not permit assessment of the underlying pathophysiology associated with disease progression or treatment response. Molecular imaging with radionuclide-based approaches, such as PET and SPECT, can offer novel insight into PVD by providing non-invasive assessment of biological processes such as angiogenesis and atherosclerosis. This review discusses emerging radionuclide-based imaging approaches that have potential clinical applications in the evaluation of PVD progression and treatment.