Inflammatory and hormonal measures predict neuropsychological functioning in systemic lupus erythematosus and rheumatoid arthritis patients
Inflammatory and hormonal measures predict neuropsychological functioning in systemic lupus erythematosus and rheumatoid arthritis patients
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DOI：
10.1017/s1355617701766106
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发表时间：
2001-09-01
影响因子：
2.6
通讯作者：
West, SG
中科院分区：
文献类型：
--
作者：
Kozora, E;Laudenslager, M;West, SG
炎症和激素水平的降低在SLE患者中很常见。虽然SLE患者存在认知功能障碍，但这些缺陷的生物学机制尚未阐明。本研究的目的是探讨炎症和激素活性与学习，流畅性和注意力的测量系统性红斑狼疮患者无神经精神症状（非中枢神经系统-SLE），类风湿关节炎（RA）患者和健康对照（HC）之间的关系。比较15例非中枢神经系统系统SLE患者、15例RA患者和15例年龄、教育程度和性别相似的TIC参与者（女性）的认知、抑郁和血浆白细胞介素-6（IL-6）、脱氢表雄酮（DHEA）、脱氢表雄酮硫酸盐（DHEA-S）和皮质醇水平。非CNS-SLE患者表现出较低的学习和较差的注意力。此外，非CNS SLE和RA患者的DHEA和DHEA-S水平显著低于HC参与者。分层回归分析表明，DHEA-S和IL-6占一个独特的一部分，在受试者的学习和注意力的措施后，控制抑郁症和皮质类固醇治疗的表现的方差。该数据突出了协变量分层分析的价值，并提供了外周细胞因子水平和认知功能之间关系的人类证据。
Abnormalities of inflammatory and hormonal measures are common in SLE patients. Although cognitive dysfunction has been documented in SLE patients, the biological mechanism of these deficits has not been clarified. The goal of this study was to explore the relationship between inflammatory and hormonal activity and measures of learning, fluency, and attention in systemic lupus erythematosus patients without neuropsychiatric symptoms (non-CNS-SLE), patients with rheumatoid arthritis (RA), and healthy controls (HC). Fifteen non-CNS-SLE patients, 15 RA patients and 15 TIC participants similar in age, education, and gender (female) were compared on tests of cognition, depression, and plasma levels of interleukin-6 (IL-6), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S) and cortisol. Non-CNS-SLE patients demonstrated lower learning and poorer attention. Furthermore, non-CNS-SLE and RA patients had significantly lower levels of DHEA and DHEA-S than HC participants. Hierarchical regression analysis demonstrates that DHEA-S and IL-6 accounts for a unique portion of the variance in subject performance on measures of learning and attention after controlling for depression and corticosteroid treatment. This data highlights the value of hierarchical analyses with covariates, and provides evidence in humans of a relationship between peripheral cytokine levels and cognitive function.