Effective treatment of ketamine-associated cystitis with botulinum toxin type a injection combined with bladder hydrodistention.
Effective treatment of ketamine-associated cystitis with botulinum toxin type a injection combined with bladder hydrodistention.
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A型肉毒毒素注射联合膀胱水扩张有效治疗氯胺酮相关性膀胱炎
DOI：
10.1177/0300060517693956
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Wei L
中科院分区：
文献类型：
--
作者：
Zeng J;Lai H;Zheng D;Zhong L;Huang Z;Wang S;Zou W;Wei L
Objective Ketamine-associated cystitis (KAC) has been described in a few case reports, but its treatment in a relatively large number of patients has not been documented. This study aimed to describe our experience of treatment of 36 patients with KAC. Methods Thirty-six patients (30 males and 6 females, aged 19–38 years) with KAC, who had previously taken a muscarinic receptor blocker and/or antibiotics, but without symptomatic relief, were treated with botulinum toxin A injection combined with bladder hydrodistention. Urodynamic testing, and the O’Leary–Sant interstitial cystitis symptom index (ICSI) and problem index (ICPI) were used to evaluate baseline values and improvement before and after the treatment. Results One month post-treatment, all patients achieved marked relief of symptoms. The nocturia time was markedly reduced, while bladder capacity, the interval between micturition, the void volume, and the maximum flow rate were remarkably increased at 1 month. Additionally, the ICSI and ICPI were significantly improved. Conclusion Botulinum toxin A injection along with bladder hydrodistention is effective for managing KAC.
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