Periodontal disease and coronary heart disease risk
Periodontal disease and coronary heart disease risk
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DOI：
10.1001/jama.284.11.1406
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发表时间：
2000-09-20
影响因子：
120.7
通讯作者：
DeRouen, TA
中科院分区：
文献类型：
--
作者：
Hujoel, PP;Drangsholt, M;DeRouen, TA
背景研究表明牙周病和冠心病（CHD）之间的关系，但这两种常见的条件之间的关联的数据是不确定的，由于混淆的可能性。目的评估牙周炎，牙龈炎，或没有牙周病的人患CHD的风险。设计前瞻性队列研究。研究对象8032名年龄在25 - 74岁之间，无心血管疾病史的成年人，其中牙周炎1859名，牙龈炎2421名，3752例牙周组织健康。主要结果测量首次发生的冠心病死亡或因冠心病住院，或血管重建手术，结果在随访期间，1265人至少有1次CHD事件，包括CHD死亡（n=468）或至少1次住院诊断CHD（n=1022），包括冠状动脉血运重建术（n=155）。在调整已知的心血管危险因素后，牙龈炎与冠心病无关（危险比，1.05; 95%置信区间）。牙周炎与冠心病的危险性无显著相关性（危险比为1.14; 95%可信区间为0.96-1.36）。
Context Research has suggested a relationship between periodontal disease and coronary heart disease (CHD), but data on the association between these 2 common conditions are inconclusive due to the possibility of confounding.Objective To evaluate the risk of CHD in persons with periodontitis, gingivitis, or no periodontal disease.Design Prospective cohort study.Setting The First National Health and Nutrition Examination Survey Epidemiologic Follow-up Study, conducted in 1982-1984, 1986, 1987, and 1992.Participants A total of 8032 dentate adults aged 25 to 74 years with no reported history of cardiovascular disease, including 1859 individuals with periodontitis, 2421 with gingivitis, and 3752 with healthy periodontal tissues.Main Outcome Measure First occurrence of death from CHD or hospitalization due to CHD, or revascularization procedures, obtained from death certificates and medical records, by baseline periodontal status.Results During follow-up, 1265 individuals had at least 1 CHD event, including CHD fatality (n=468) or at least 1 hospitalization with a diagnosis of CHD (n=1022), including coronary revascularization procedures (n=155). After adjustment for known cardiovascular risk factors, gingivitis was not associated with CHD (hazard ratio, 1.05; 95% confidence interval. 0.88-1.26), while periodontitis was associated with a nonsignificant increased risk for CHD event (hazard ratio, 1.14; 95% confidence interval, 0.96-1.36).Conclusion This study did not find convincing evidence of a causal association be tween periodontal disease and CHD risk.