Effects of the DNA state fluctuation on single-cell dynamics of self-regulating gene.
Effects of the DNA state fluctuation on single-cell dynamics of self-regulating gene.
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DOI：
10.1063/1.2768353
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发表时间：
2007-05
期刊：
影响因子：
--
通讯作者：
Y. Okabe;Y. Yagi;M. Sasai
中科院分区：
文献类型：
--
作者：
Y. Okabe;Y. Yagi;M. Sasai
提出了一种分析基因表达的随机单细胞动力学的动力学平均场理论。通过考虑DNA态涨落的非平衡和非绝热特性，导出了单细胞动力学的两次关联函数和响应函数。该方法被应用到一个自我调节的基因来预测丰富多样的动力学现象，如异常增加的弛豫时间和振荡衰减的相关性。当DNA状态变化频繁时，定义为相关性与蛋白质数量响应之比的有效“温度”很小，而当DNA状态变化不频繁时，它变大，表明在后一种情况下噪声的强烈增强。
A dynamical mean-field theory is developed to analyze stochastic single-cell dynamics of gene expression. By explicitly taking account of nonequilibrium and nonadiabatic features of the DNA state fluctuation, two-time correlation functions and response functions of single-cell dynamics are derived. The method is applied to a self-regulating gene to predict a rich variety of dynamical phenomena such as an anomalous increase of relaxation time and oscillatory decay of correlations. The effective "temperature" defined as the ratio of the correlation to the response in the protein number is small when the DNA state change is frequent, while it grows large when the DNA state change is infrequent, indicating the strong enhancement of noise in the latter case.