Corticosteroid-binding globulin affects the relationship between circulating adiponectin and cortisol in men and women
Corticosteroid-binding globulin affects the relationship between circulating adiponectin and cortisol in men and women
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DOI：
10.1016/j.metabol.2004.11.015
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发表时间：
2005-05-01
影响因子：
9.8
通讯作者：
Ricart, W
中科院分区：
文献类型：
--
作者：
Fernandez-Real, JM;Pugeat, M;Ricart, W
人们越来越认识到炎症途径与人类的胰岛素抵抗密切相关。脂联素基因的启动子区域Apm1包含糖皮质激素受体反应元件的共同序列。地塞米松在体外诱导脂联素分泌下调，而强的松龙治疗则增加循环中的脂联素浓度。由于先前的研究表明皮质类固醇结合球蛋白(CBG)、体重指数和胰岛素抵抗之间存在负相关，我们研究了CBG是否可以解释皮质醇和脂联素的关系。用放射免疫法测定血浆CBG和血清皮质醇浓度。用皮质醇/CBG比值计算游离皮质醇。使用RIA试剂盒(密苏里州圣路易斯的Linco Research)测量脂联素水平。循环脂联素与血清CBG呈正相关(r=0.38，P
Inflammatory pathways are increasingly recognized to be tightly associated with insulin resistance in humans. The promoter region of the adiponectin gene-Apm1 -encompasses consensus sequences for glucocorticosteroid receptor responsive element. Dexamethasone induced downregulation Of adiponectin secretion in vitro, whereas prednisolone administration increased circulating adiponectin concentrations. As previous studies have demonstrated an inverse relationship between corticosteroid-binding globulin (CBG), body mass index, and insulin resistance, we studied whether CBG could explain cortisol-to-adiponectin relationship.One hundred twenty-two healthy subjects were enrolled in a cross-sectional study. Plasma CBG and serum cortisol concentration were measured by radioimmunoassay. The cortisol-to-CBG ratio was used to calculate free cortisol. An RIA kit (Linco Research, St Louis, Mo) was used to measure adiponectin levels. Insulin resistance was calculated using the homeostatis model of assessment (HOMA) value.Circulating adiponectin was associated with serum CBG (r = 0.38, P