Infectious agent of sheep scrapie may persist in the environment for at least 16 years
Infectious agent of sheep scrapie may persist in the environment for at least 16 years
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DOI：
10.1099/vir.0.82011-0
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发表时间：
2006-12-01
影响因子：
3.8
通讯作者：
Brown, Paul
中科院分区：
文献类型：
--
作者：
Georgsson, Gudmundur;Sigurdarson, Sigurdur;Brown, Paul
1978年，冰岛实施了一项严格的计划，以阻止羊瘙痒病的传播，并随后根除羊瘙痒病。受影响的羊群被扑杀，场所进行消毒，并在2-3年后，重新放养来自无羊瘙痒症地区的羔羊。1978年至2004年，羊瘙痒症在33个农场复发。其中9例复发发生在扑杀后14-21年，显然是环境污染的结果，但不能总是绝对排除外部进入。特别有趣的是一个农场，有一个小的，完全独立的羊群，羊瘙痒症复发18年后，扑杀，2年后，一些羔羊已被安置在一个旧的羊舍，从来没有消毒。流行病学调查几乎确定该疾病不是从外部引入的，并得出结论，该病原体可能在旧羊舍中持续存在至少16年。
In 1978, a rigorous programme was implemented to stop the spread of, and subsequently eradicate, sheep scrapie in Iceland. Affected flocks were culled, premises were disinfected and, after 2-3 years, restocked with lambs from scrapie-free areas. Between 1978 and 2004, scrapie recurred on 33 farms. Nine of these recurrences occurred 14-21 years after culling, apparently as the result of environmental contamination, but outside entry could not always be absolutely excluded. Of special interest was one farm with a small, completely self-contained flock where scrapie recurred 18 years after culling, 2 years after some lambs had been housed in an old sheephouse that had never been disinfected. Epidemiological investigation established with near certitude that the disease had not been introduced from the outside and it is concluded that the agent may have persisted in the old sheep-house for at least 16 years.