Tongalides, Halogenated Butenolides from an Antarctic Delisea sp. Rhodophyte.
Tongalides, Halogenated Butenolides from an Antarctic Delisea sp. Rhodophyte.
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Tongalides，来自南极 Delisea sp 的卤化丁烯内酯。
DOI：
10.1021/acs.jnatprod.2c00344
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发表时间：
2022
影响因子：
5.1
通讯作者：
Baker,BillJ
中科院分区：
文献类型：
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作者：
Bracegirdle,Joe;Kennedy,SarahJ;Shan,Chuan;Wojtas,Lukasz;Shaw,LindseyN;Amsler,CharlesD;McClintock,JamesB;Baker,BillJ
从南极红藻Deliseasp 的提取物中分离出六种新的卤代丁烯内酯，tongalides A–C (1–3) 及其乙酰化同系物 (4–6)。显示出显着的抗生素活性。通过分析光谱和光谱技术（包括 NMR、HRESIMS、旋光度和 X 射线衍射研究）获得的数据来确定化合物的结构。对新分离的化合物进行了抗菌活性测定，但未表现出对 ESKAPE 病原体生长的抑制作用。提取物的生物活性归因于先前报道的 Z-乙酰氧基芬溴内酯 A，该化合物也从提取物中分离出来，这进一步证明环外双键对于结构相关的芬溴内酯类代谢物的抗菌活性至关重要。
Six new halogenated butenolides, tongalides A–C (1–3) and their acetylated congeners (4–6), were isolated from an extract of the Antarctic rhodophyteDeliseasp. that displayed significant antibiotic activity. The structures of the compounds were determined by analysis of data acquired by spectroscopic and spectrometric techniques including NMR, HRESIMS, optical rotation, and X-ray diffraction studies. The newly isolated compounds were assayed for antibacterial activity, but exhibited no growth inhibition of ESKAPE pathogens. The extract bioactivity was attributed to the previously reportedZ-acetoxyfimbrolide A also isolated from the extract, providing further evidence that the exocyclic double bond is essential to the antibacterial activity of the structurally related fimbrolide class of metabolite.