Diabetes and Metabolic Drivers of Trained Immunity: New Therapeutic Targets Beyond Glucose.
Diabetes and Metabolic Drivers of Trained Immunity: New Therapeutic Targets Beyond Glucose.
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培训免疫的糖尿病和代谢驱动因素：葡萄糖以外的新治疗靶标。
DOI：
10.1161/atvbaha.120.314211
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发表时间：
2021-04
影响因子：
8.7
通讯作者：
Fisher, Edward A.
中科院分区：
文献类型：
--
作者：
Choudhury, Robin P.;Edgar, Laurienne;Ryden, Mikael;Fisher, Edward A.
越来越多的证据表明，新陈代谢、免疫、组织动态平衡和造血等多种生理功能是如何在多个层面错综复杂地交织在一起的。这篇简短的综述将提供来自快速扩展的免疫代谢领域的证据，强调与决定血管健康和疾病的过程相关的细胞如何通过其代谢环境的变化来编程。它将专注于如何印记或训练这种变化，特别是通过表观遗传修饰，以便由代谢信号驱动的适应可以导致细胞功能的持续变化，即使在原始刺激已被纠正或移除之后。认识到这些过程并阐明其机制对于糖尿病及相关代谢状态的诊断和治疗具有深远的意义。本文提供了一个图形摘要。
Accumulating evidence shows how diverse physiological functions, such as metabolism, immunity, tissue homeostasis, and hematopoiesis, are intricately and profoundly intertwined at multiple levels. This brief review will present evidence from a rapidly expanding field of immunometabolism, highlighting how cells that are relevant to processes at play in determining vascular health and disease can be programmed by changes in their metabolic environment. It will focus on how such changes can be imprinted or trained, particularly through epigenetic modifications, such that adaptations driven by metabolic signals can cause persistent changes in cell function, even after the original stimulus has been corrected or removed. Recognition of these processes and elucidation of the mechanisms underlying them stand to have far-reaching implications for the diagnosis and treatment of diabetes and related metabolic states. A graphic abstract is available for this article.