Treatment of antibody-mediated pure red-cell aplasia with high-dose intravenous gamma globulin.
Treatment of antibody-mediated pure red-cell aplasia with high-dose intravenous gamma globulin.
复制标题
用高剂量静脉注射丙种球蛋白治疗抗体介导的纯红细胞再生障碍性贫血。
DOI：
10.1056/nejm198710153171606
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Hoffman,R
中科院分区：
文献类型：
--
作者：
McGuire,WA;Yang,HH;Bruno,E;Brandt,J;Briddell,R;Coates,TD;Hoffman,R
PURE red-cell aplasia is a syndrome characterized by severe anemia, reticulocytopenia, and an absence of erythroid precursor cells in bone marrow that is otherwise normal. This failure of erythropoiesis has been shown to be antibody-mediated in almost half the patients with the adult form of red-cell aplasia.1234Immunosuppressive agents such as corticosteroids, cyclophosphamide, and antithymocyte globulin have been used to treat immunologically mediated red-cell aplasia.2,5678Results of in vitro assays for hematopoietic progenitor cells may assist in predicting which patients will respond to immunosuppressive therapy.91011Red-cell aplasia in children usually differs from the disorder in adults. There is a constitutional . . .
