Palladium-Catalyzed Coupling of Functionalized Primary and Secondary Amines with Aryl and Heteroaryl Halides: Two Ligands Suffice in Most Cases.
Palladium-Catalyzed Coupling of Functionalized Primary and Secondary Amines with Aryl and Heteroaryl Halides: Two Ligands Suffice in Most Cases.
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DOI：
10.1039/c0sc00330a
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发表时间：
2011-01-01
期刊：
影响因子：
8.4
通讯作者：
Buchwald SL
中科院分区：
文献类型：
--
作者：
Maiti D;Fors BP;Henderson JL;Nakamura Y;Buchwald SL
我们报道了我们对基于配体BrettPhos（1）和RuPhos（2）的两种催化剂体系的使用的研究，这两种催化剂体系为迄今为止Pd催化的C-N交叉偶联反应提供了最广泛的范围。通常，低催化剂负载和短反应时间可与官能化芳基和杂芳基偶联配偶体一起使用。反应是高度稳健的，并且可以在不使用手套箱的情况下设置和进行。这些催化剂在药物、天然产物和功能材料等复杂分子的合成中具有广泛的应用前景。
We report our studies on the use of two catalyst systems, based on the ligands BrettPhos (1) and RuPhos (2), which provide the widest scope for Pd-catalyzed C–N cross-coupling reactions to date. Often low catalyst loadings and short reaction times can be used with functionalized aryl and heteroaryl coupling partners. The reactions are highly robust and can be set up and performed without the use of a glovebox. These catalysts should find wide application in the synthesis of complex molecules including pharmaceuticals, natural products and functional materials.