A NOVEL INTEGRIN (ALPHA-E-BETA-4) FROM HUMAN EPITHELIAL-CELLS SUGGESTS A 4TH FAMILY OF INTEGRIN ADHESION RECEPTORS
A NOVEL INTEGRIN (ALPHA-E-BETA-4) FROM HUMAN EPITHELIAL-CELLS SUGGESTS A 4TH FAMILY OF INTEGRIN ADHESION RECEPTORS
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DOI：
10.1002/j.1460-2075.1989.tb03425.x
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发表时间：
1989-03-01
期刊：
影响因子：
11.4
通讯作者：
QUARANTA, V
中科院分区：
文献类型：
--
作者：
KAJIJI, S;TAMURA, RN;QUARANTA, V
从人上皮细胞中分离出粘附受体整合素超家族的一个新成员。与其他整合素类似，该分子是由结构上不相关的亚基组成的异源二聚体，两者都是糖基化的。在这些亚基和整联蛋白α之间观察到明确的氨基酸序列同源性。和β链序列，表明这种上皮异源二聚体是一种新的整合素。与其他整合素无明显血清学交叉反应。的β上皮整合素的分子量为1.25。wt显著高于其它整联蛋白β。链，可能是由于大量的唾液酸含量。整合素异二聚体分为三个家族，基于三个β-整合素异二聚体中的哪一个。它们所含的链（β 1、β 2和β 3）。因此，上皮整联蛋白可以代表第四整联蛋白家族的原型，因为它含有结构上不同的β。链建议将这种新的人整联蛋白命名为α E β 4。
A new member of the integrin superfamily of adhesion receptors was isolated from human epithelial cells. Analogously to other integrins, this molecule is a heterodimer comprised of structurally unrelated subunits, both glycosylated. Unequivocal amino-acid sequence homologies were observed between these subunits and integrin .alpha. and .beta. chain sequences, indicating that this epithelial heterodimer is a novel integrin. No obvious serologic cross-reactivities were detected with other integrins. The .beta. chain of the epithelial integrin displayed a mol. wt significantly higher than other integrin .beta. chains, possibly due to a large sialic acid content. Integrin heterodimers are grouped into three families, based on which of three .beta. chains (.beta.1, .beta.2 and .beta.3) they contain. Therefore, the epithelial integrin may represent the prototype of a fourth integrin family, because it contains a structurally distinct .beta. chain. The designation .alpha.E.beta.4 is proposed for this novel human integrin.