Functional Connectivity Changes of the Visual Cortex in the Cervical Spondylotic Myelopathy Patients A Resting-State fMRI Study
Functional Connectivity Changes of the Visual Cortex in the Cervical Spondylotic Myelopathy Patients A Resting-State fMRI Study
复制标题
脊髓型颈椎病患者视觉皮层功能连接的变化：静息态功能磁共振成像研究
DOI：
10.1097/brs.0000000000003245
复制
发表时间：
2020-03-01
期刊：
影响因子：
3
通讯作者：
Xue, Yuan
中科院分区：
文献类型：
--
作者：
Chen, Zhao;Zhao, Rui;Xue, Yuan
研究设计。横断面研究。目的 利用静息态功能磁共振成像 (fMRI) 分析脊髓型颈椎病 (CSM) 患者视觉皮层功能连接 (FC) 的改变。背景数据摘要。我们之前展示了 CSM 患者视觉皮层神经活动的变化。方法。招募了 30 名 CSM 患者和 20 名健康对照。使用 3.0 T MR 收集 MR 数据。以体素方式计算感兴趣区域 (ROI)（布罗德曼面积 [BA] 17/18/19/7）的 FC，并在组间进行比较。对术前日本骨科协会 (JOA) 评分与改变的 FC 之间以及术前最佳矫正视力 (BCVA) 与改变的 FC 之间进行相关性分析。此外，以 ROI 方式比较术前和术后 CSM 患者的 FC。结果。 BA19和小脑下叶之间发现FC增加；左侧 BA7 与双侧距状体、右侧舌回、右侧梭状回和左侧楔前叶之间（BA17）；左侧 BA7 与右侧梭状回和右侧枕下回（右侧 BA19）之间； CSM 患者的右 BA7 和小脑右上叶（右 BA19）之间的差异（P < 0.05）。左右BA19的JOA评分与FC呈负相关，左右BA7的BCVA与FC呈正相关（P < 0.05）。 ROI 分析显示 CSM 患者术前和术后 FC 差异具有统计学意义（P < 0.05）。结论。 CSM患者视觉皮层存在FC变化，与术前JOA评分呈负相关，与术前BCVA呈正相关。 CSM 患者术后视觉皮层 FC 显着恢复。
Study Design. Cross-sectional study. Objective To analyze altered functional connectivity (FC) in the visual cortex of cervical spondylotic myelopathy (CSM) patients using resting-state functional magnetic resonance imaging (fMRI). Summary of Background Data. We previously showed changes in visual cortex neural activity in CSM patients. Methods. Thirty CSM patients and 20 healthy controls were recruited. MR data were collected using a 3.0 T MR. FC of the regions of interest (ROI) (Brodmann areas [BA] 17/18/19/7) were calculated in a voxel-wise manner and compared between groups. Correlation analyses were performed between preoperative Japanese Orthopaedic Association (JOA) scores and altered FC, as well as between preoperative best corrected visual acuity (BCVA) and altered FC. Furthermore, the FC where was compared between the preoperative and the postoperative CSM patients in an ROI-wise manner. Results. Increased FC was found between BA19 and the cerebellum inferior lobe; between the left BA7 and bilateral calcarine, right lingual, right fusiform gyrus, and left precuneus (BA17); between the left BA7 and right fusiform gyrus and right inferior occipital gyrus (right BA19); and between the right BA7 and right superior lobe of cerebellum (right BA19) in CSM patients (P < 0.05). A negative correlation was found between JOA score and FC of the left and right BA19, and a positive correlation was found between the BCVA and FC of the left and right BA7 (P < 0.05). ROI analysis demonstrated statistically significant FC differences in between the preoperative and the postoperative CSM patients (P < 0.05). Conclusion. FC changes were present in the visual cortex of CSM patients, which negatively correlated with preoperative JOA scores and positively correlated with preoperative BCVA. Significant recovery of FC in the visual cortex was detected in CSM patients postoperatively.