Enantioselective Synthesis of Planar Chiral Ferrocenes via Pd(0)-Catalyzed Intramolecular Direct C-H Bond Arylation
Enantioselective Synthesis of Planar Chiral Ferrocenes via Pd(0)-Catalyzed Intramolecular Direct C-H Bond Arylation
复制标题
Pd(0)催化分子内直接C-H键芳基化对映选择性合成平面手性二茂铁
DOI：
10.1021/ja500444v
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发表时间：
2014-04-02
影响因子：
15
通讯作者：
You, Shu-Li
中科院分区：
文献类型：
--
作者：
Gao, De-Wei;Yin, Qin;You, Shu-Li
在温和的反应条件下，以现成的原料为原料，采用Pd(0)催化的对映选择性直接C-H基化反应，高效合成了平面手性二茂铁（产率高达99%，ee达99%）。产物可以很容易地转化为高效的平面二茂铁配体，在pd催化的不对称烯丙基烷基化和胺化反应中表现出高效率。
A highly efficient synthesis of planar chiral ferrocenes by enantioselective Pd(0)-catalyzed direct C-H arylation from readily available starting materials under mild reaction conditions was developed (up to 99% yield, 99% ee). The products can be easily transformed to the highly efficient planar ferrocene ligands, which have demonstrated high efficiency in Pd-catalyzed asymmetric allylic alkylation and amination reactions.