Glutamate receptors in the rat medial prefrontal cortex regulate set-shifting ability
Glutamate receptors in the rat medial prefrontal cortex regulate set-shifting ability
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DOI：
10.1037/0735-7044.117.4.728
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发表时间：
2003-08-01
影响因子：
1.9
通讯作者：
Moghaddam, B
中科院分区：
文献类型：
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作者：
Stefani, MR;Groth, K;Moghaddam, B
作者检查了向内侧前额叶皮层（mPFC）注射N-甲基-D-天冬氨酸（NMDA）受体（MK 801）或α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）受体（LY 293558）拮抗剂的大鼠的定势转换能力。集移位进行了评估与迷宫为基础的任务，需要亮度和纹理歧视策略之间的切换。在第二次辨别训练之前，mPFC内注射MK 801会损害辨别策略的获得。MK 801诱导的缺陷是由于持续反应增加。AMPA受体阻断也损害了第二种辨别能力的获得;这些损害是由于更普遍的认知缺陷。结果表明，在mPFC，AMPA和NMDA受体是必要的设置移位，和NMDA受体功能减退损害的能力，修改现有的知识或抑制反应，不再适当。
The authors examined set-shifting abilities in rats injected with antagonists of N-methyl-D-aspartate (NMDA) receptors (MK801) or alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors (LY293558) into the medial prefrontal cortex (mPFC). Set-shifting was assessed with a maze-based task requiring a switch between brightness and texture discrimination strategies. Intra-mPFC injection of MK801 prior to training on the 2nd discrimination impaired discrimination strategy acquisition. The MK801-induced deficit was due to increased perseverative responding. AMPA receptor blockade also impaired acquisition of the 2nd discrimination; these impairments were due to more general cognitive deficits. Results suggest that, within the mPFC, both AMPA and NMDA receptors are necessary for set-shifting, and that NMDA receptor hypofunction impairs the capacity to modify existing knowledge or to inhibit responses that are no longer appropriate.