The Rat Prelimbic Cortex Mediates Inhibitory Response Control But Not the Consolidation of Instrumental Learning
The Rat Prelimbic Cortex Mediates Inhibitory Response Control But Not the Consolidation of Instrumental Learning
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DOI：
10.1037/a0016330
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发表时间：
2009-08-01
影响因子：
1.9
通讯作者：
Everitt, Barry J.
中科院分区：
文献类型：
--
作者：
Jonkman, Sietse;Mar, Adam C.;Everitt, Barry J.
目前尚不确定大鼠大脑皮层在获得仪器性反应中的潜在作用。此外，对巴甫洛夫任务和空间条件作用任务的习得建模表明，对于某些形式的学习，习得的过程可能是阶梯式的，因此在平均组曲线中被曲解了。在这里，作者报告了一项实验，该实验调查了前额叶皮质在工具习得中的潜在参与，在该实验中，作者使用对照数据对个体获取曲线进行了数学建模。研究结果表明，在固定时间间隔下的乐器习得是一个渐进的过程，历时4次，在平均群体曲线中得到了很好的体现。会后将蛋白质合成抑制剂注入前脑皮质不影响任何习得措施，表明在习得过程中，前脑皮质并不调节会后工具性学习的巩固。然而，失活的前皮质增加了反应，这表明前皮质介导了一种形式的抑制反应控制。
The potential role of the prelimbic cortex of the rat in the acquisition of instrumental responding is currently uncertain. In addition, modeling the acquisition of Pavlovian and spatial conditioning tasks has suggested that the process of acquisition can, for certain forms of learning, be step like and consequently misrepresented in averaged group curves. Here, the authors report an experiment investigating the potential involvement of the prelimbic cortex in instrumental acquisition, in which the authors used the control data to model individual acquisition curves mathematically. The authors show that instrumental acquisition under fixed interval schedules was a gradual process extending over 4 instrumental sessions that is well represented in averaged group curves. Postsession infusion of a protein synthesis inhibitor into the prelimbic cortex did not affect any measure of acquisition, showing that during acquisition the prelimbic cortex does not mediate postsession consolidation of instrumental learning. However, inactivation of the prelimbic cortex increased responding, suggesting that the prelimbic cortex mediates a form of inhibitory response control.