Adrenergic receptors in man: direct identification, physiologic regulation, and clinical alterations.
Adrenergic receptors in man: direct identification, physiologic regulation, and clinical alterations.
复制标题
人类肾上腺素能受体：直接识别、生理调节和临床改变。
DOI：
10.1056/nejm198207013070104
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Insel,PA
中科院分区：
文献类型：
--
作者：
Motulsky,HJ;Insel,PA
儿茶酚胺、去甲肾上腺素和肾上腺素是人类许多生理事件的关键调节剂；去甲肾上腺素主要作为交感神经末梢释放的神经递质，肾上腺素作为肾上腺髓质释放的循环激素。这些儿茶酚胺通过与特定识别位点（肾上腺素能受体）结合来启动靶细胞反应。受体是细胞外信息的最初解码器，这一概念多年来一直指导着激素和神经递质作用的研究。对肾上腺素能受体的研究首先集中于肾上腺素能刺激所促进的生理反应，并证明了两种主要类型的肾上腺素能受体的存在。 。 。
THE catecholamines norepinephrine and epinephrine are key regulators of many physiologic events in human beings; norepinephrine acts primarily as a neurotransmitter released from sympathetic-nerve terminals, and epinephrine functions as a circulating hormone released from the adrenal medulla. These catecholamines initiate target-cell responses by binding to specific recognition sites, the adrenergic receptors. That receptors are the initial decoders of extracellular messages is a concept that has guided research on hormone and neurotransmitter action for many years. Studies of adrenergic receptors focused first on physiologic responses that are promoted by adrenergic stimulation and demonstrated the existence of two primary types of adrenergic . . .