Adipokines - removing road blocks to obesity and diabetes therapy.
Adipokines - removing road blocks to obesity and diabetes therapy.
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DOI：
10.1016/j.molmet.2014.01.005
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发表时间：
2014-06
影响因子：
8.1
通讯作者：
Blüher M
中科院分区：
文献类型：
--
作者：
Blüher M
预防肥胖症和治疗性减肥干预措施只能带来有限的长期成功。因此，迫切需要开发新的药物治疗策略，针对正能量平衡、过度脂肪积聚和不利脂肪分布的潜在机制。脂肪因子参与调节食欲和饱腹感、能量消耗、内皮功能、血压、胰岛素敏感性、脂肪生成、脂肪分布和胰岛素分泌等，有可能成为未来肥胖和代谢性疾病的药物治疗策略。从候选脂肪因子到临床使用治疗化合物的道路上有重要的障碍。这些障碍包括对作用机制的不完全了解，对特定脂肪因子的抵抗，脂肪因子的副作用等。本综述重点介绍了部分脂肪因子作为治疗工具或靶点的潜力，并讨论了目前阻碍其临床应用的重要障碍。
Prevention of obesity and therapeutic weight loss interventions have provided only limited long term success. Therefore there is an urgent need to develop novel pharmacological treatment strategies, which target mechanisms underlying positive energy balance, excessive fat accumulation and adverse fat distribution. Adipokines may have potential for future pharmacological treatment strategies of obesity and metabolic diseases, because they are involved in the regulation of appetite and satiety, energy expenditure, endothelial function, blood pressure, insulin sensitivity, adipogenesis, fat distribution and insulin secretion and others. There are important road blocks on the way from an adipokine candidate to the clinical use a therapeutic compound. Such road blocks include an incomplete understanding of the mechanism of action, resistance to a specific adipokine, side effects of the adipokine and others. This review focuses on the potential of selected adipokines as therapeutic tools or targets and discusses important road blocks, which currently prevent their clinical use.
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影响因子：
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通讯作者：
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