Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer 1 Fertility preservation for female patients with childhood , adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group
Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer 1 Fertility preservation for female patients with childhood , adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group
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DOI：
10.1016/s1470-2045(20)30594-5
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发表时间：
2021-02-01
期刊：
影响因子：
51.1
通讯作者：
Tissing, Wim J. E.
中科院分区：
文献类型：
--
作者：
Mulder, Renee L.;Font-Gonzalez, Anna;Tissing, Wim J. E.
当治疗对生殖器官功能产生不利影响时，患有儿童、青少年和青年癌症的女性患者生育能力受损的风险增加。患者及其家属渴望生儿育女，但临床实践指南的实质性变化减少了各机构对生育能力保存有效干预措施的一致和及时实施。作为PanCareLIFE联盟的一部分，并与国际儿童癌症晚期效应指南协调小组合作，我们回顾了目前的文献，并制定了25岁或以下被诊断为儿童、青少年和青年癌症的女性患者保留生育能力的临床实践指南，包括风险评估和保留生育能力的可用方法指南。建议分级评估、发展和评价方法用于对现有证据进行分级并形成建议。本临床实践指南利用现有证据和国际专业知识，制定易于使用的透明建议，以促进对患有生育障碍高风险的儿童、青少年和青年癌症的女性患者的护理。对现有证据的全面审查，包括质量评估、指南小组决定的透明报告以及全球跨学科共识的达成，是这一密集合作的重要成果。
Female patients with childhood, adolescent, and young adult cancer are at increased risk for fertility impairment when treatment adversely affects the function of reproductive organs. Patients and their families desire biological children but substantial variations in clinical practice guidelines reduce consistent and timely implementation of effective interventions for fertility preservation across institutions. As part of the PanCareLIFE Consortium, and in collaboration with the International Late Effects of Childhood Cancer Guideline Harmonization Group, we reviewed the current literature and developed a clinical practice guideline for fertility preservation in female patients who were diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger, including guidance on risk assessment and available methods for fertility preservation. The Grading of Recommendations Assessment, Development and Evaluation methodology was used to grade the available evidence and to form the recommendations. This clinical practice guideline leverages existing evidence and international expertise to develop transparent recommendations that are easy to use to facilitate the care of female patients with childhood, adolescent, and young adult cancer who are at high risk for fertility impairment. A complete review of the existing evidence, including a quality assessment, transparent reporting of the guideline panel's decisions, and achievement of global interdisciplinary consensus, is an important result of this intensive collaboration.