From shavenbaby to the naked valley: trichome formation as a model for evolutionary developmental biology
From shavenbaby to the naked valley: trichome formation as a model for evolutionary developmental biology
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DOI：
10.1111/ede.12113
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发表时间：
2015-01-01
影响因子：
2.9
通讯作者：
McGregor, Alistair P.
中科院分区：
文献类型：
--
作者：
Arif, Saad;Kittelmann, Sebastian;McGregor, Alistair P.
微毛或毛状体是由许多昆虫的表皮细胞产生的非感官肌动蛋白突起。在过去的30年里，对果蝇毛状体形成的研究为我们理解基因调控、基因调控网络(GRN)、发育、基因到表型的图谱以及这些过程的进化提供了关键的见解。在这里，我们回顾了使用毛状体作为模型来阐明果蝇发育的经典研究，以及最近关于毛状体基础结构的GRN的研究。这包括发现小肽和microRNAs在这个网络的调节和进化中都扮演着重要的角色。此外，我们综述了毛状体模式进化的研究，这些研究为顺式调控模块的功能和结构以及形态变化的遗传基础提供了新的见解。我们的结论是，对这些看似简单且往往功能神秘的结构的进一步研究将继续提供关于发育和进化的新的重要知识。
Microtrichia or trichomes are non-sensory actin protrusions produced by the epidermal cells of many insects. Studies of trichome formation in Drosophila have over the last 30 years provided key insights towards our understanding of gene regulation, gene regulatory networks (GRNs), development, the genotype to phenotype map, and the evolution of these processes. Here we review classic studies that have used trichome formation as a model to shed light on Drosophila development as well as recent research on the architecture of the GRN underlying trichome formation. This includes the findings that both small peptides and microRNAs play important roles in the regulation and evolution of this network. In addition, we review research on the evolution of trichome patterns that has provided novel insights into the function and architecture of cis-regulatory modules, and into the genetic basis of morphological change. We conclude that further research on these apparently simple and often functionally enigmatic structures will continue to provide new and important knowledge about development and evolution.