Embryotoxicity and Biotransformation Responses in Zebrafish Exposed to Water-Soluble Fraction of Crude Oil
Embryotoxicity and Biotransformation Responses in Zebrafish Exposed to Water-Soluble Fraction of Crude Oil
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DOI：
10.1007/s00128-011-0235-x
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发表时间：
2011-03
影响因子：
2.7
通讯作者：
Luciana M Pauka;M. Maceno;S. Rossi;H. C. Silva de Assis
中科院分区：
文献类型：
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作者：
Luciana M Pauka;M. Maceno;S. Rossi;H. C. Silva de Assis
研究了巴西坎波斯盆地API27原油的水溶部分(WSF)在斑马鱼早期生活阶段的毒性效应及其在幼鱼体内的生物转化。在96h内对胚胎发育进行了研究。在所有测试浓度的WSF中，都观察到心跳减少、弱色素沉着、尾巴缺陷和胚胎死亡。生物转化酶的活性在最高浓度下被诱导，表明这些酶在其消除过程中起到了作用。本研究表明，原油WSF改变了鱼类的正常胚胎发育。
The toxic effects of water-soluble fraction (WSF) of crude oil (API27, Petrobras Campos Basin, Brazil) were evaluated during the early life stages of zebrafish, as well as its biotransformation in juvenile fish. Embryonic development was studied during 96 h. Reduced heartbeat rate, weak pigmentation, tail defects, and embryo mortality were observed for all of the tested concentrations of the WSF. Activities of the biotransformation enzymes were induced at the highest concentrations, showing that these enzymes played a role in its elimination. As shown in this study the crude oil WSF altered the normal embryonic development of fish.